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Paediatric brain-stem gliomas: MRI, FDG-PET and histological grading correlation

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Authors
Kwon, Jong Won; Kim, In-One; Cheon, Jung-Eun; Kim, Woo Sun; Moon, Sung Gyu; Kim, Tae Jung; Chi, Je Geun; Wang, Kyu-Chang; Chung, June Key; Yeon, Kyung Mo
Issue Date
2006-07-18
Publisher
Springer Verlag
Citation
Pediatr Radiol 36(9):959-964
Keywords
Brain stemBrain neoplasmsMRIPETChildrenBrain Stem Neoplasms/*diagnosis/pathology/radionuclideDiagnosis, DifferentialChild, Preschoolimaging/surgeryNeoplasm StagingRadiopharmaceuticals/diagnostic use
Abstract
BACKGROUND: MRI and FDG-PET may predict the histological grading of paediatric brain-stem gliomas. OBJECTIVE: To assess MRI findings and metabolic imaging using FDG-PET of brain-stem gliomas based on histological grading. MATERIALS AND METHODS: Included in the study were 20 paediatric patients (age 3-14 years, mean 8.2 years) with brain-stem glioma (five glioblastomas, ten anaplastic astrocytomas and five low-grade astrocytomas). MR images were assessed for the anatomical site of tumour origin, focality, pattern of tumour growth, and enhancement. RESULTS: All glioblastomas were located in the pons and showed diffuse pontine enlargement with focally exophytic features. Eight anaplastic astrocytomas were located in the pons and demonstrated diffuse pontine enlargement without exophytic features. Low-grade astrocytomas were located in the pons, midbrain or medulla and showed focally exophytic growth features and peripheral enhancement. In 12 patients in whom FDG-PET was undertaken, glioblastomas showed hypermetabolic or hypometabolic lesions, anaplastic astrocytomas showed no metabolic change or hypometabolic lesions and low-grade astrocytomas showed hypometabolism compared with the cerebellum. CONCLUSION: MRI findings correlated well with histological grading of brain-stem gliomas and MRI may therefore predict the histological grading. FDG-PET may be helpful in differentiating between anaplastic astrocytoma and glioblastomas among high-grade tumours.
ISSN
0301-0449 (Print)
1432-1998 (Electronic)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16847598

http://hdl.handle.net/10371/10080
DOI
https://doi.org/10.1007/s00247-006-0256-5
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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