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First-trimester screening for Down syndrome; the role of nasal bone assessment in the Korean population
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Min Hoan | - |
dc.contributor.author | Cho, Jeong Yeon | - |
dc.contributor.author | Lee, Yu Mi | - |
dc.contributor.author | Jung, Sung Il | - |
dc.contributor.author | Yang, Jae Hyug | - |
dc.contributor.author | Kim, Moon Young | - |
dc.contributor.author | Ryu, Hyun-Mee | - |
dc.contributor.author | Chung, Jin Hoon | - |
dc.contributor.author | Park, Seong Ho | - |
dc.date.accessioned | 2009-10-13T23:21:08Z | - |
dc.date.available | 2009-10-13T23:21:08Z | - |
dc.date.issued | 2007-06-29 | - |
dc.identifier.citation | Prenat Diagn ;27: 830-834 | en |
dc.identifier.issn | 0197-3851 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17605156 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10419 | - |
dc.description.abstract | OBJECTIVES: The aim of this study was to evaluate the role of nasal bone assessment in first-trimester screening for Down syndrome (DS) in the Korean population. METHODS: From July 2004 to March 2006, we prospectively evaluated the fetal nasal bones at 11-14 weeks' gestation in the Korean population. RESULTS: A successful evaluation was possible in 6490 of 6787 fetuses (95.6%). Absent, hypoechoic, and short nasal bones were seen in 4 (26.7%), 4 (26.7%), and 1 (6.7%) of 15 fetuses with DS, respectively, whereas in 5 (0.1%), 11 (0.2%), and 246 (3.8%) of 6456 normal fetuses. The incidence of absent and hypoechoic nasal bone showed significant differences between normal fetuses and fetuses with DS (P < 0.0005, both). Screening for DS using an absent or hypoechoic nasal bone resulted in a sensitivity of 53.3%, a specificity of 99.8%, a positive likelihood ratio of 215.2, and a negative likelihood ratio of 0.5. CONCLUSION: Our study showed that nasal bone abnormality at 11-14 weeks of gestation had a high association with DS in the Korean population. This suggests that nasal bone assessment can be used to supplement the current first-trimester screening for DS in the Korean population. | en |
dc.language.iso | en | en |
dc.publisher | Wiley | en |
dc.subject | Down Syndrome/*diagnosis | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Nasal Bone/*anatomy & histology/embryology/ultrasonography | en |
dc.subject | Pregnancy | en |
dc.subject | Prospective Studies | en |
dc.subject | Ultrasonography, Prenatal | en |
dc.subject | Pregnancy Trimester, First | - |
dc.title | First-trimester screening for Down syndrome; the role of nasal bone assessment in the Korean population | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문민환 | - |
dc.contributor.AlternativeAuthor | 조정연 | - |
dc.contributor.AlternativeAuthor | 이유미 | - |
dc.contributor.AlternativeAuthor | 정성일 | - |
dc.contributor.AlternativeAuthor | 양재혁 | - |
dc.contributor.AlternativeAuthor | 김문영 | - |
dc.contributor.AlternativeAuthor | 류현미 | - |
dc.contributor.AlternativeAuthor | 정진훈 | - |
dc.contributor.AlternativeAuthor | 박성호 | - |
dc.identifier.doi | 10.1002/pd.1785 | - |
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