S-Space College of Medicine/School of Medicine (의과대학/대학원) Dept. of Radiation Applied Life Science (대학원 협동과정 방사선응용생명과학전공) Journal Papers (저널논문_방사선응용생명과학전공)
Concurrent radiotherapy with paclitaxel/carboplatin chemotherapy as a definitive treatment for squamous cell carcinoma of the uterine cervix
- Lee, Me-Yeon; Wu, Hong-Gyun; Kim, Kyubo; Ha, Sung Whan; Kim, Jae Sung; Kim, In Ah; Lee, Hyo-Pyo
- Issue Date
- Gynecol Oncol 2007;104:95-9
- Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols/adverse; effects/*therapeutic use; Carboplatin/administration & dosage/adverse effects; Carcinoma, Squamous Cell/*drug therapy/pathology/*radiotherapy; Combined Modality Therapy; Female; Humans; Middle Aged; Neoplasm Staging; Paclitaxel/administration & dosage/adverse effects; Retrospective Studies; Survival Rate; Uterine Cervical Neoplasms/*drug therapy/pathology/*radiotherapy
- OBJECTIVES: To evaluate the toxicity and the efficacy of paclitaxel/carboplatin chemoradiotherapy as a definitive treatment for squamous cell cancer of the uterine cervix. METHODS: From March 2000 to January 2004, 33 patients with squamous cell cancer of the uterine cervix were treated with concurrent chemoradiotherapy including 2 cycles of paclitaxel (135 mg/m(2)) and carboplatin (area under the time-concentration curve 4.5 mg min/ml) at 4-week interval. Seven patients received adjuvant chemotherapy with the same chemotherapeutic regimen. All patients received external beam radiotherapy with 41.4-51.4 Gy (median 50.4 Gy) to the whole pelvis. Twenty-eight patients received boost irradiation to the cervix by brachytherapy with 25.6-43.3 Gy (median 34.6 Gy) and 5 patients by external beam radiotherapy with 10.8-14.4 Gy (median 14.4 Gy). RESULTS: A median follow-up period was 27 months (range: 6-53 months). Acute hematological toxicity of grade 3 or 4 developed in 20 patients (61%), and acute gastrointestinal toxicity of grade 3 developed in 1 patient (3%). Vesicovaginal fistula occurred in 2 patients (6%). All patients achieved objective response (CR 70%, PR 30%) in 2 months after termination of treatment. One patient had a local progression in cervix, and 4 patients developed distant metastases. The 3-year estimated disease-free survival rates for stages I-IIA, IIB, III and IV were 67%, 91%, 88% and 50%, respectively. The 3-year estimated survival rates for stages I-IIA, IIB, III and IV were 89%, 91%, 88% and 50%, respectively. CONCLUSION: Concurrent chemoradiotherapy with paclitaxel and carboplatin is effective to achieve an excellent pelvic control.
- 0090-8258 (Print)
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