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Erythrodiol-3-acetate, pentacyclic triterpenoid from Styrax japonica, expressions of matrix metalloproteinase-1,2 in cultured human skin fibroblasts

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Authors
Moon, Hyung-In; Seo, Dong Wan; Kim, Kyu-Han; Cho, Kwang-Hyun; Eun, Hee-Chul; Chung, Jin Ho
Issue Date
2005
Publisher
Elsevier
Citation
J Ethnopharmacol. 2005 Mar 21;97(3):567-71.
Keywords
Styrax japonicaErythrodiol-3-acetateMMP-1MMP-2
Abstract
Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of erythrodiol-3-acetate on the expressions of MMP-1,2 in cultured human skin fibroblasts. Erythrodiol-3-acetate was isolated from the stems of Styrax japonica (Styracaceae). Erythrodiol-3-acetate reduced the expression of MMP-1 but not MMP-2, at the mRNA and protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that erythrodiol-3-acetate an important role in the reduction of MMP-1 induction by ultraviolet irradiation.
ISSN
0378-8741 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15740897

http://hdl.handle.net/10371/10891
DOI
https://doi.org/10.1016/j.jep.2005.01.006
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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