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Surgical treatment of giant cell tumour of long bone with anhydrous alcohol adjuvant

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Authors
Oh, Joo Han; Yoon, Pil Whan; Lee, Sang Hoon; Cho, Hwan Seong; Kim, Woo Sung; Kim, Han-Soo
Issue Date
2006
Publisher
Springer Verlag
Citation
Int Orthop 30:490-494
Keywords
*Bone Neoplasms/drug therapy/surgeryBone Transplantation/*adverse effectsChemotherapy, Adjuvant/methodsChemotherapy, Cancer, Regional Perfusion/methodsCombined Modality TherapyEthanol/*administration & dosageFibula/surgery*Giant Cell Tumor of Bone/drug therapy/surgeryKaplan-Meiers Estimate*Neoplasm Recurrence, LocalRetrospective StudiesTibia/surgery
Abstract
This study was designed to evaluate the feasibility and effectiveness of the use of anhydrous alcohol as an adjuvant treatment for giant cell tumours (GCTs) of long bone. Between October 1989 and January 2004, 42 GCT patients were treated and followed up for an average of 4.1 years (range 1-13 years). Mean patient age was 34 years (range 17-67 years). After curettage and additional burring, anhydrous alcohol was used as an adjuvant therapy in all patients before the bone defect was filled with bone graft or cement. Four patients (9.5%) experienced local recurrence. There were no alcohol-related complications. Recurrence-free probability was 87.6% at final follow-up (13 years) after index surgery by Kaplan-Meyer analysis. Our data suggest that anhydrous alcohol can be used as an effective safe adjuvant for the treatment of GCT of long bone.
ISSN
0341-2695 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16736146

http://hdl.handle.net/10371/10909
DOI
https://doi.org/10.1007/s00264-006-0154-3
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College of Medicine/School of Medicine (의과대학/대학원)Orthopedic Surgery (정형외과학전공)Journal Papers (저널논문_정형외과학전공)
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