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Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Sewon | - |
dc.contributor.author | Cho, Soyun | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.contributor.author | Hammerberg, Craig | - |
dc.contributor.author | Fisher, Gary J. | - |
dc.contributor.author | Voorhees, John J. | - |
dc.date.accessioned | 2009-10-29T05:51:35Z | - |
dc.date.available | 2009-10-29T05:51:35Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Am J Pathol 2005, 166:1691-1699 | en |
dc.identifier.issn | 0002-9440 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15920154 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10913 | - |
dc.description.abstract | Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics and isotretinoin (Accutane), have limited use. Thus, development of novel agents to treat this disease is needed. However, the pathophysiology of acne inflammation is poorly understood. Before new therapeutic strategies can be devised, knowledge regarding molecular mechanisms of acne inflammation is required. We report here that transcription factors nuclear factor-kappaB and activator protein-1 are activated in acne lesions with consequent elevated expression of their target gene products, inflammatory cytokines and matrix-degrading metalloproteinases, respectively. These elevated gene products are molecular mediators of inflammation and collagen degradation in acne lesions in vivo. This new knowledge enables a rational strategy for development of pharmacological agents that can target the inflammation and matrix remodeling that occurs in severe acne. | en |
dc.description.sponsorship | Supported in part by the Babcock Endowment for Dermatological Research
and the National Institutes of Health (K24 to S.K.). | en |
dc.language.iso | en | - |
dc.publisher | American Society for Investigative Pathology | en |
dc.subject | Acne Vulgaris/*physiopathology | en |
dc.subject | Blotting, Western | en |
dc.subject | Cytokines/metabolism | en |
dc.subject | Extracellular Matrix/metabolism/*pathology | en |
dc.subject | Gene Expression Regulation | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Inflammation/*physiopathology | en |
dc.subject | Matrix Metalloproteinases/metabolism | en |
dc.subject | Models, Biological | en |
dc.subject | NF-kappa B/*metabolism | en |
dc.subject | Procollagen/metabolism | en |
dc.subject | RNA, Messenger/analysis | en |
dc.subject | Reverse Transcriptase Polymerase Chain Reaction | en |
dc.subject | Signal Transduction/physiology | en |
dc.subject | Skin/metabolism/pathology | en |
dc.subject | Transcription Factor AP-1/*metabolism | en |
dc.title | Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 강세원 | - |
dc.contributor.AlternativeAuthor | 조소연 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
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