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Increased expression of 14-3-3varepsilon protein in intrinsically aged and photoaged human skin in vivo

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Authors
Choi, Kyung-Chul; Lee, Serah; Kwak, Sun Young; Kim, Mi-Sun; Choi, Hyo Kyoung; Kim, Kyu Han; Chung, Jin Ho; Park, Seok Hee
Issue Date
2005
Publisher
Elsevier
Citation
Mech Ageing Dev. 126, 629-636
Keywords
Skin agingProteomics14-3-3eUV irradiation
Abstract
Skin aging is a complicated process associated with the passage of time and environmental exposure, especially to UV light. This aging phenomenon is related to alterations in various cellular mechanisms, such as changes in apoptosis, perturbations to cellular signaling, and an increased genetic instability. In this study, we investigated changes of proteins involved in intrinsic aging by the proteomic analysis of human sun-protected (upper inner arm) young and aged dermis. One of the proteins upregulated in aged dermis was identified as 14-3-3epsilon. This protein is an isoform of 14-3-3 protein, which is involved in cellular processes like signal transduction, cell cycle arrest, and apoptosis. 14-3-3epsilon is consistently found to be upregulated in the sun-protected dermis of aged skin, by Western blotting and immunohistochemical staining. In addition, we demonstrate that the expression of 14-3-3epsilon is further upregulated in the sun-exposed (photodamaged) dermis, and that the UV irradiation of young skin significantly upregulates 14-3-3epsilon in vivo. Our results suggest the possibility that the cellular processes related to 14-3-3epsilon protein play an important role in the photoaging and intrinsic aging of human skin.
ISSN
0047-6374 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15888315

http://hdl.handle.net/10371/10917
DOI
https://doi.org/10.1016/j.mad.2004.11.013
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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