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The role of the brain-derived neurotrophic factor genotype and parenting in early life in predicting externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder
Cited 6 time in
Web of Science
Cited 7 time in Scopus
- Authors
- Issue Date
- 2014-11-25
- Publisher
- BioMed Central
- Citation
- Behavioral and Brain Functions, 10(1):43
- Abstract
- Background
We aimed to determine whether early parenting is associated with externalizing and internalizing symptoms in children with attention-deficit hyperactivity disorder (ADHD) and whether such an association is affected by the brain-derived neurotrophic factor (BDNF) val66met polymorphism.
Methods
The participants included 92 patients with ADHD aged 6–15 years. Measures of parenting in early life and externalizing and internalizing symptoms and the genotype of the BDNF Val66Met polymorphism were obtained.
Results
The degree to which the babys autonomy was allowed was significantly and negatively correlated with the CDI scores in ADHD children (r = −0.38, p = 0.005). After adjusting for the childs gender, the childs age, the familys gross annual income, and the maternal education level, there was a significant interaction for the BDNF genotype and mothers positive feelings about caring in relation to the development of childhood anxiety/depression in ADHD children (F = 2.51, p = 0.011).
Conclusions
Our results provide evidence of an interaction between the BDNF met allele and early parenting on the development of depression/anxiety symptoms.
- Language
- English
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