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Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A
Cited 31 time in
Web of Science
Cited 33 time in Scopus
- Authors
- Issue Date
- 2006
- Publisher
- Blackwell Publishing
- Citation
- Photochem. Photobiol. 82, 574-578
- Keywords
- Cell Line ; Cyanides/*pharmacology ; Dose-Response Relationship, Drug ; Eurotiales/*chemistry ; Keratinocytes/cytology/*drug effects/physiology ; Matrix Metalloproteinase 2/genetics/metabolism ; Matrix Metalloproteinase 9/genetics/metabolism ; Mice, Hairless ; Phototherapy/methods ; Proteins/analysis/metabolism ; RNA, Messenger/analysis/metabolism ; Skin Aging/*drug effects/physiology/radiation effects ; Time Factors ; Ultraviolet Rays/*adverse effects
- Abstract
- Repetitive exposure of the skin to UV radiation induces various harmful changes, such as thickening, wrinkle formation, inflammation and carcinogenesis. A variety of natural compounds and synthetic compounds have been studied to determine whether they can prevent UV-induced harmful effects. In this study, we investigated the effect of a novel compound, Melanocin A, which was isolated from Eupenicillium shearii F80695, on UV-induced premature skin aging. First, we studied the effect of Melanocin A on UV-induced matrix metalloproteinase (MMP)-9 expression in an immortalized human keratinocyte cell line, HaCaT, in vitro. Acute UV irradiation induced MMP-9 expression at both the mRNA and protein levels and Melanocin A suppressed this expression in a dose-dependent manner. We then investigated the effect of Melanocin A on UV-induced skin changes in hairless mice in vivo. Chronic exposure of hairless mouse dorsal skin to UV increased skin thickness and induced wrinkle formation and the gelatinase activities of MMP-2 and MMP-9. Moreover, Melanocin A significantly suppressed UV-induced morphologic skin changes and MMP-2 and MMP-9 expression. Taken together, these results show that Melanocin A can prevent the harmful effects of UV that lead to skin aging. Therefore, we suggest that Melanocin A should be viewed as a potential therapeutic agent for preventing and/or treating premature skin aging.
- ISSN
- 0031-8655 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16613515
https://hdl.handle.net/10371/11044
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