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Granulocyte colony-stimulating factor stimulates neurogenesis via vascular endothelial growth factor with STAT activation

Cited 76 time in Web of Science Cited 77 time in Scopus
Authors
Jung, Keun-Hwa; Chu, Kon; Lee, Soon-Tae; Kim, Se-Jeong; Sinn, Dong-In; Kim, Seung U.; Kim, Manho; Roh, Jae-Kyu
Issue Date
2006
Publisher
Elsevier
Citation
Brain Res. 1073-1074, 190-201
Keywords
Granulocyte colony-stimulatingfactor (G-CSF)NeurogenesisG-CSFRSTATVEGF
Abstract
The adult brain harbors multipotent stem cells, which reside in specialized niches that support self-renewal. Granulocyte colony-stimulating factor (G-CSF) induces bone marrow stem cells proliferation and mobilization from their niche, and activates endothelial cell proliferation, which might help to establish a vascular niche for neural stem cells (NSCs). Here, we show that G-CSF induced receptor-mediated proliferation and differentiation of neural precursors in human NSCs cultures and in adult rat brain in vivo. In human NSCs cultures, G-CSF activated STAT3 and 5, and increased VEGF and its receptor, VEGFR2 (Flk-1) expression, and VEGFR2 tyrosine kinase inhibitor blocked the neurogenesis stimulated by G-CSF. G-CSF also activated endothelial cell proliferation in adult rat brain in vivo. Our results indicate that G-CSF stimulates neurogenesis through reciprocal interaction with VEGF and STAT activation.
ISSN
0006-8993 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6SYR-4J2TSRB-9&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fc1cd00aeeb342a383d5fa2a1a7434a5

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16423324

http://hdl.handle.net/10371/11093
DOI
https://doi.org/10.1016/j.brainres.2005.12.037
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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