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Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage

Cited 36 time in Web of Science Cited 34 time in Scopus
Authors
Sinn, Dong-In; Lee, Soon-Tae; Chu, Kon; Jung, Keun-Hwa; Song, Eun-Cheol; Kim, Jeong-Min; Park, Dong-Kyu; Kim, Manho; Roh, Jae-Kyu
Issue Date
2007
Publisher
Elsevier
Citation
Neurosci Lett. 411 (2007) 238-242
Keywords
Intracerebral hemorrhageMemantineCelecoxibAnti-inflammationExcitotoxicity
Abstract
Memantine, a N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits hematoma expansion and celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, reduces perihematomal inflammation in intracerebral hemorrhage. We examined whether the combination treatment has additive effects in experimental intracerebral hemorrhage (ICH). ICH was induced using stereotaxic infusion of collagenase into brains of adult rats. After the induction of ICH, rats were treated with intraperitoneal injection of memantine (20 mg/kg), celecoxib (20 mg/kg) or both agents. Only vehicles were administrated in rats of the control group. Results showed that the combination treatment of memantine and celecoxib reduced both hematoma volume and brain edema. Combination treatment also induced the better functional recovery with further attenuation of cerebral inflammation and apoptosis compared to the control group. When compared to the single agent groups, the combination treatment showed better effects in neuroprotection and anti-inflammation. These results suggest the feasible combined application of memantine and celecoxib in ICH treatment.
ISSN
0304-3940 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17123715

http://hdl.handle.net/10371/11114
DOI
https://doi.org/10.1016/j.neulet.2006.10.050
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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