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The importance of maximal airway response to methacholine in the prediction of asthma development in patients with allergic rhinitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koh, Y. Y. | - |
dc.contributor.author | Kang, E. K. | - |
dc.contributor.author | Min, Y-G. | - |
dc.contributor.author | Kim, C. K. | - |
dc.date.accessioned | 2009-11-04T06:21:22Z | - |
dc.date.available | 2009-11-04T06:21:22Z | - |
dc.date.issued | 2002-06-06 | - |
dc.identifier.citation | Clin Exp Allergy 2002; 32:921-7 | en |
dc.identifier.issn | 0954-7894 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12047440 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11118 | - |
dc.description.abstract | BACKGROUND: Allergic rhinitis is a known predictor and correlate of asthma incidence. However, it is not clear which patients with allergic rhinitis are at greater risk of the development of asthma. OBJECTIVE: The aim of this study was to investigate whether airway hypersensitivity and/or increased maximal response on the dose-response curve to methacholine would predict the development of asthma in subjects with allergic rhinitis. METHODS: One hundred and forty-one children with allergic rhinitis were prospectively studied for 7 years. At the initiation of the study, bronchial provocation test with methacholine using a stepwise increasing concentration technique was performed to measure PC(20) (provocative concentration causing a 20% fall in FEV(1)) and maximal response. Each subject was evaluated at least every 6 months and details of asthmatic symptoms or signs experienced during the intervening period were taken. RESULTS: Twenty of 122 subjects available for the follow-up developed asthma. Nine (19.6%) of 46 hypersensitive (PC(20) < 18 mg/mL) subjects developed asthma, compared with 11 (14.5%) of 76 normosensitive subjects (P = 0.462). Eight (32%) of 25 subjects without maximal response plateau developed asthma, compared with 12 (12.4%) of 97 subjects with maximal response plateau (P = 0.018). Score test for trend revealed a significant association between the level of maximal response (P = 0.007), but not the degree of methacholine PC(20) (P = 0.123), and the future development of asthma. CONCLUSION: An increased maximal airway response to methacholine is shown to be a better predictor for the future development of asthma in patients with allergic rhinitis, than airway hypersensitivity to methacholine. | en |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing | en |
dc.subject | allergic rhinitis | en |
dc.subject | asthma | en |
dc.subject | airway hyper-responsiveness | en |
dc.subject | methacholine | en |
dc.subject | maximal airway response | en |
dc.subject | PC20 | en |
dc.title | The importance of maximal airway response to methacholine in the prediction of asthma development in patients with allergic rhinitis | en |
dc.type | Article | en |
dc.identifier.doi | 10.1046/j.1365-2222.2002.01399.x | - |
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