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Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Takamura, Kaoru | - |
dc.contributor.author | Fukuyama, Satoshi | - |
dc.contributor.author | Nagatake, Takahiro | - |
dc.contributor.author | Kim, Dong-Young | - |
dc.contributor.author | Kawamura, Aya | - |
dc.contributor.author | Kawauchi, Hideyuki | - |
dc.contributor.author | Kiyono, Hiroshi | - |
dc.date.accessioned | 2009-11-04T09:21:05Z | - |
dc.date.available | 2009-11-04T09:21:05Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | J. Immunol. 179, 5897-5906 | en |
dc.identifier.issn | 0022-1767 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17947663 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11165 | - |
dc.description.abstract | The lymphoid chemokines CCL19 and CCL21 are known to be crucial both for lymphoid cell trafficking and for the structural organization of lymphoid tissues such as nasopharynx-associated lymphoid tissue (NALT). However, their role in allergic responses remains unclear, and so our current study aims to shed light on the role of CCL19/CCL21 in the development of allergic rhinitis. After nasal challenge with OVA, OVA-sensitized plt (paucity of lymph node T cells) mice, which are deficient in CCL19/CCL21, showed more severe allergic symptoms than did identically treated wild-type mice. OVA-specific IgE production, eosinophil infiltration, and Th2 responses were enhanced in the upper airway of plt mice. Moreover, in plt mice, the number of CD4(+)CD25(+) regulatory T cells declined in the secondary lymphoid tissues, whereas the number of Th2-inducer-type CD8alpha(-)CD11b(+) myeloid dendritic cells (m-DCs) increased in cervical lymph nodes and NALT. Nasal administration of the plasmid-encoding DNA of CCL19 resulted in the reduction of m-DCs in the secondary lymphoid tissues and the suppression of allergic responses in plt mice. These results suggest that CCL19/CCL21 act as regulatory chemokines for the control of airway allergic disease and so may offer a new strategy for the control of allergic disease. | en |
dc.language.iso | en | en |
dc.publisher | American Association of Immunologists | en |
dc.subject | Cell Differentiation | en |
dc.subject | Chemokine CCL19/genetics/*metabolism | en |
dc.subject | Chemokine CCL21/genetics/*metabolism | en |
dc.subject | DNA/genetics | en |
dc.subject | Dendritic Cells/cytology | en |
dc.subject | Hypersensitivity/metabolism/pathology | en |
dc.subject | Immunoglobulin E/biosynthesis/immunology | en |
dc.subject | Lymphocyte Count | en |
dc.subject | Lymphoid Tissue/*metabolism | en |
dc.subject | Mice, Inbred BALB C | en |
dc.subject | Rhinitis/*metabolism/pathology | en |
dc.subject | T-Lymphocytes, Regulatory/cytology | en |
dc.subject | Th1 Cells/metabolism | en |
dc.subject | Th2 Cells/metabolism | en |
dc.title | Regulatory role of lymphoid chemokine CCL19 and CCL21 in the control of allergic rhinitis | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김동영 | - |
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