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Role of surgical salvage for regional recurrence in laryngeal cancer

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Authors
Jeong, Woo-Jin; Jung, Young Ho; Kwon, Seong Keun; Hah, J. Hun; Kwon, Tack-Kyun; Sung, Myung-Whun; Kim, Kwang Hyun
Issue Date
2006
Publisher
Laryngoscope
Citation
Laryngoscope 2007;117:74-77
Keywords
Carcinoma, Squamous Cell/mortality/*surgeryKaplan-Meiers EstimateLaryngeal Neoplasms/mortality/*surgery*Neck Dissection/mortalityNeoplasm Recurrence, Local/*surgeryRetrospective Studies*Salvage TherapySurvival Rate
Abstract
OBJECTIVES: The aims of this study were to analyze the pattern of regional recurrence in laryngeal cancer, evaluate the role of surgical salvage, and identify factors affecting salvage outcome. METHODS: Retrospective analysis was conducted on medical records from a 16-year period. Of 463 patients diagnosed with laryngeal cancer, 25 patients with regional recurrence managed with salvage neck dissection were identified and subject to study. Isolated local recurrences and all distant metastases were excluded. RESULTS: All patients were male with a median age of 61 years. The overall rate of regional recurrence was 5.4%. Median time to regional recurrence was 13 months. Isolated regional recurrence occurred in 76% of cases, whereas locoregional recurrence occurred in 24%. A 5-year survival rate for patients undergoing neck dissection as salvage management was 61.2%. Patients with recurrence in the contralateral neck were definitely associated with poor prognosis. Although standard statistical significance was not met, trends for poorer salvage result were identified in patients with a history of local recurrence before regional recurrence, recurrence in a previously dissected neck, and recurred node size of 3 cm or above. CONCLUSIONS: Our study shows that salvage neck dissection for regional recurrence in laryngeal cancer is an acceptable approach. Surgical eradication of disease should be warranted whenever possible. Prudent planning of management is mandatory in the presence of history of local recurrence before regional recurrence, previously dissected neck, large size of recurrent node, and contralateral neck recurrence.
ISSN
0023-852X (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17202934

http://hdl.handle.net/10371/11190
DOI
https://doi.org/10.1097/01.mlg.0000240184.75588.dc
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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