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Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Kim, Kang Mo | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Lee, Tae-Rim | - |
dc.contributor.author | Suh, Kyung Suk | - |
dc.contributor.author | Lee, Kuhn Uk | - |
dc.contributor.author | Chung, Jin Wook | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Kim, Chung Yong | - |
dc.date.accessioned | 2009-11-05T22:55:15Z | - |
dc.date.available | 2009-11-05T22:55:15Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | J Clin Oncol 20:4459-4465 | en |
dc.identifier.issn | 0732-183X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12431969 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11306 | - |
dc.description.abstract | PURPOSE: Identifying a special subgroup of hepatocellular carcinoma (HCC) patients who may benefit from transcatheter arterial chemoembolization (TACE) when compared with the standard treatment of hepatic resection (HR) warrants research in Asian countries. PATIENTS AND METHODS: From January 1993 to December 1994, 182 patients with operable HCC (Child-Pugh class A and International Union Against Cancer [UICC] stage T1-3N0M0) were enrolled. After initial TACE and lipiodol computed tomography, 91 received HR and 91, who refused the operation, received repeated sessions of TACE. After stratification according to the tumor stage (UICC and Cancer of the Liver Italian Program [CLIP]) and lipiodol retention pattern, the survival rates of the two treatment groups were compared. The median follow-up period was 83 months. RESULTS: As of December 31, 2000, 48 patients who underwent HR and 68 patients who underwent TACE had died. In a subgroup analysis according to tumor stage, the HR group survival rate was significantly higher than the TACE group in both UICC T1-2N0M0 (P =.0058) and CLIP 0 (P =.0027) subgroups. However, there was no significant difference in either UICC T3N0M0 (P =.7512) or CLIP 1-2 (P =.5366) subgroups. Even in patients with UICC T1-2N0M0 HCC, when lipiodol was compactly retained, the survival rate of the HR group was comparable to that of the TACE group (P =.0596). CONCLUSION: TACE proved to be as effective as HR in the subpopulations with UICC T3N0M0 or CLIP 1-2 HCC and adequate liver function, and even with UICC T1-2N0M0 HCC when lipiodol was compactly retained in the tumor. In such cases, the choice of treatment modality between TACE and HR may be left to the patient's preference. | en |
dc.language.iso | en | - |
dc.publisher | American Society of Clinical Oncology | en |
dc.subject | Carcinoma, | en |
dc.subject | Hepatocellular/complications/pathology/*physiopathology/surgery/*therapy | en |
dc.subject | Catheters, Indwelling | en |
dc.subject | Cohort Studies | en |
dc.subject | Contrast Media | en |
dc.subject | Hepatic Artery | en |
dc.subject | Hepatitis B/*complications/*epidemiology/physiopathology | en |
dc.subject | Infusions, Intra-Arterial | en |
dc.subject | Iodized Oil/diagnostic use | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Liver Neoplasms/complications/pathology/*physiopathology/surgery/*therapy | en |
dc.subject | Neoplasm Staging | en |
dc.subject | Prospective Studies | en |
dc.subject | Survival Analysis | en |
dc.subject | Tomography, X-Ray Computed/methods | en |
dc.subject | Treatment Outcome | en |
dc.subject | Chemoembolization, Therapeutic/methods | - |
dc.subject | Hepatectomy | - |
dc.title | Therapeutic efficacy of transcatheter arterial chemoembolization as compared with hepatic resection in hepatocellular carcinoma patients with compensated liver function in a hepatitis B virus-endemic area: a prospective cohort study | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 김강모 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 이태림 | - |
dc.contributor.AlternativeAuthor | 서경석 | - |
dc.contributor.AlternativeAuthor | 이건욱 | - |
dc.contributor.AlternativeAuthor | 정진욱 | - |
dc.contributor.AlternativeAuthor | 박재형 | - |
dc.contributor.AlternativeAuthor | 김정용 | - |
dc.identifier.doi | 10.1200/JCO.2002.02.013 | - |
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