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Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans

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dc.contributor.authorLee, Kyung-Taeen
dc.contributor.authorSo, Yee-Seul-
dc.contributor.authorYang, Dong-Hoon-
dc.contributor.authorJung, Kwang-Woo-
dc.contributor.authorChoi, Jaeyoung-
dc.contributor.authorLee, Dong-Gi-
dc.contributor.authorKwon, Hyojeong-
dc.contributor.authorJang, Juyeong-
dc.contributor.authorWang, Li Li-
dc.contributor.authorCha, Soohyun-
dc.contributor.authorMeyers, Gena Lee-
dc.contributor.authorJeong, Eunji-
dc.contributor.authorJin, Jae-Hyung-
dc.contributor.authorLee, Yeonseon-
dc.contributor.authorHong, Joohyeon-
dc.contributor.authorBang, Soohyun-
dc.contributor.authorJi, Je-Hyun-
dc.contributor.authorPark, Goun-
dc.contributor.authorByun, Hyo-Jeong-
dc.contributor.authorPark, Sung Woo-
dc.contributor.authorPark, Young-Min-
dc.contributor.authorAdedoyin, Gloria-
dc.contributor.authorKim, Taeyup-
dc.contributor.authorAverette, Anna F.-
dc.contributor.authorChoi, Jong-Soon-
dc.contributor.authorHeitman, Joseph-
dc.contributor.authorCheong, Eunji-
dc.contributor.authorLee, Yong-Hwan-
dc.contributor.authorBahn, Yong-Sun-
dc.date.accessioned2017-04-19T00:19:46Z-
dc.date.available2017-07-31T22:21:23Z-
dc.date.issued2016-09-28-
dc.identifier.citationNATURE COMMUNICATIONS Vol.7, pp. 12766-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10371/116883-
dc.description.abstractCryptococcus neoformans is the leading cause of death by fungal meningoencephalitis; however, treatment options remain limited. Here we report the construction of 264 signature-tagged gene-deletion strains for 129 putative kinases, and examine their phenotypic traits under 30 distinct in vitro growth conditions and in two different hosts (insect larvae and mice). Clustering analysis of in vitro phenotypic traits indicates that several of these kinases have roles in known signalling pathways, and identifies hitherto uncharacterized signalling cascades. Virulence assays in the insect and mouse models provide evidence of pathogenicity-related roles for 63 kinases involved in the following biological categories: growth and cell cycle, nutrient metabolism, stress response and adaptation, cell signalling, cell polarity and morphology, vacuole trafficking, transfer RNA (tRNA) modification and other functions. Our study provides insights into the pathobiological signalling circuitry of C. neoformans and identifies potential anticryptococcal or antifungal drug targets.en
dc.language.isoenen
dc.publisherNATURE PUBLISHING GROUPen
dc.subjectSystematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformansen
dc.subject자연과학en
dc.titleSystematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformansen
dc.typeArticleen
dc.contributor.AlternativeAuthor이경태-
dc.contributor.AlternativeAuthor소이슬-
dc.contributor.AlternativeAuthor양동훈-
dc.contributor.AlternativeAuthor정광우-
dc.contributor.AlternativeAuthor최재영-
dc.contributor.AlternativeAuthor이동기-
dc.contributor.AlternativeAuthor권효정-
dc.contributor.AlternativeAuthor장주영-
dc.contributor.AlternativeAuthor차수현-
dc.contributor.AlternativeAuthor정은지-
dc.contributor.AlternativeAuthor진재형-
dc.contributor.AlternativeAuthor이연선-
dc.contributor.AlternativeAuthor홍주현-
dc.contributor.AlternativeAuthor방수현-
dc.contributor.AlternativeAuthor지제현-
dc.contributor.AlternativeAuthor박고운-
dc.contributor.AlternativeAuthor변효정-
dc.contributor.AlternativeAuthor박성우-
dc.contributor.AlternativeAuthor박영민-
dc.contributor.AlternativeAuthor김태엽-
dc.contributor.AlternativeAuthor최종순-
dc.contributor.AlternativeAuthor정은지-
dc.contributor.AlternativeAuthor이용환-
dc.contributor.AlternativeAuthor반용선-
dc.identifier.doi10.1038/ncomms12766-
dc.description.srndOAIID:RECH_ACHV_DSTSH_NO:T201615370-
dc.description.srndRECH_ACHV_FG:RR00200001-
dc.description.srndADJUST_YN:-
dc.description.srndEMP_ID:A003535-
dc.description.srndCITE_RATE:11.329-
dc.description.srndFILENAME:4. ncomms12766.pdf-
dc.description.srndDEPT_NM:농생명공학부-
dc.description.srndEMAIL:yonglee@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/fce63c4a-7de7-4741-996f-d8d24af38905/link-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid10200-
dc.identifier.srndT201615370-
dc.type.rimsART-
Appears in Collections:
College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Journal Papers (저널논문_농생명공학부)
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