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Comparative genomic analysis reveals genetic features related to the virulence of Bacillus cereus FORC_013
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koo, Hyun-Jin | - |
dc.contributor.author | Ahn, Sojin | - |
dc.contributor.author | Chung, Han Young | - |
dc.contributor.author | Kim, Suyeon | - |
dc.contributor.author | Kim, Kwondo | - |
dc.contributor.author | Ryu, Sangryeol | - |
dc.contributor.author | Lee, Ju-Hoon | - |
dc.contributor.author | Choi, Sang Ho | - |
dc.contributor.author | Kim, Heebal | - |
dc.date.accessioned | 2017-05-26T01:03:19Z | - |
dc.date.available | 2017-05-26T10:25:33Z | - |
dc.date.issued | 2017-05-15 | - |
dc.identifier.citation | Gut Pathogens, 9(1):29 | ko_KR |
dc.identifier.uri | 10.1186/s13099-017-0175-z | - |
dc.identifier.uri | https://hdl.handle.net/10371/117610 | - |
dc.description.abstract | Background
Bacillus cereus is well known as a gastrointestinal pathogen that causes food-borne illness. In the present study, we sequenced the complete genome of B. cereus FORC_013 isolated from fried eel in South Korea. To extend our understanding of the genomic characteristics of FORC_013, we conducted a comparative analysis with the published genomes of other B. cereus strains. Results We fully assembled the single circular chromosome (5,418,913bp) and one plasmid (259,749bp); 5511 open reading frames (ORFs) and 283 ORFs were predicted for the chromosome and plasmid, respectively. Moreover, we detected that the enterotoxin (NHE, HBL, CytK) induces food-borne illness with diarrheal symptom, and that the pleiotropic regulator, along with other virulence factors, plays a role in surviving and biofilm formation. Through comparative analysis using the complete genome sequence of B. cereus FORC_013, we identified both positively selected genes related to virulence regulation and 224 strain-specific genes of FORC_013. Conclusions Through genome analysis of B. cereus FORC_013, we identified multiple virulence factors that may contribute to pathogenicity. These results will provide insight into further studies regarding B. cereus pathogenesis mechanism at the genomic level. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Bacillus cereus | ko_KR |
dc.subject | Virulence | ko_KR |
dc.subject | Comparative genomics | ko_KR |
dc.subject | Positive selection | ko_KR |
dc.subject | Unique genes | ko_KR |
dc.title | Comparative genomic analysis reveals genetic features related to the virulence of Bacillus cereus FORC_013 | ko_KR |
dc.type | Article | ko_KR |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2017-05-21T03:35:27Z | - |
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