Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils

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Kim, Y-K; Oh, S-Y; Oh, H-B; Chun, S-Y; Cho, S-H; Koh, Y-Y; Min, K-U; Kim, Y-Y
Issue Date
Blackwell Publishing
Clin Exp Allergy. 2002 May;32(5):751-5.
AdolescentAllelesAsthma/*geneticsBasophils/*immunology/metabolismCalcimycin/pharmacologyChildFemaleHistamine Release/drug effects/physiologyHumansMalePolymorphism, Single NucleotideRandom AllocationReceptors, IgE/*genetics/*physiology
BACKGROUND: Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located. OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. METHODS: Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods. RESULTS: The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens. CONCLUSION: This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils.
0954-7894 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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