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Free fatty acid metabolism in human skeletal muscle is regulated by PPARgamma and RXR agonists

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Authors
Ciaraldi, Theodore P; Cha, Bong-Soo; Park, Kyong-Soo; Carter, Leslie; Mudaliar, Sunder R; Henry, Robert R
Issue Date
2002-06-25
Publisher
Blackwell Publishing
Citation
Ann N Y Acad Sci. 2002 Jun;967:66-70.
Keywords
Fatty Acids, Nonesterified/*metabolismHumansMuscle, Skeletal/*metabolismOxidation-ReductionReceptors, Cytoplasmic and Nuclear/*agonistsReceptors, Retinoic Acid/*agonistsTranscription Factors/*agonists
Abstract
Free fatty acid (FFA) oxidation in human skeletal muscle cells can be stimulated, both independently and in a synergistic manner, by agonists for PPARgamma and RXR. Increased FFA disposal in muscle through augmented oxidation could reduce intramyocellular lipid accumulation. The abilities of such agents to improve glucose tolerance and insulin action may thus involve effects on both glucose and FFA metabolism.
ISSN
0077-8923 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12079836

http://hdl.handle.net/10371/11793
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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