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Attenuation of transforming growth factor beta-induced growth inhibition in human hepatocellular carcinoma cell lines by cyclin D1 overexpression
DC Field | Value | Language |
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dc.contributor.author | Jong, Hyun-Soon | - |
dc.contributor.author | Lee, Ho Soon | - |
dc.contributor.author | Kim, Tae You | - |
dc.contributor.author | Im, Young-Hyuck | - |
dc.contributor.author | Park, Jae-Won | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.date.accessioned | 2009-11-10T14:31:12Z | - |
dc.date.available | 2009-11-10T14:31:12Z | - |
dc.date.created | 2020-12-23 | - |
dc.date.issued | 2002-03 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.292 No.2, pp.383-389 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 119619 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11867 | - |
dc.description.abstract | Transforming growth factor-beta1 (TGF-beta1) causes growth inhibition in many cell types. Since its role in the outgrowth of human hepatocellular carcinoma (HCC) is not clearly understood, we investigated the growth inhibitory effects of TGF-beta1, the genetic and molecular integrity of TGF-beta receptors, and the expression levels of cell cycle regulating proteins in 11 human HCC cell lines. Of 11 cell lines, 3 (27%) showed growth inhibition to TGF-beta1, whereas the other 8 cell lines did not. We performed Southern and Northern analysis of TGF-beta type I and II receptors and examined poly-adenine track mutation of the TGF-beta type II receptor, but failed to find any genetic mutation. The transcriptional induction of plasminogen activator inhibitor-1 and p21(WAF1/CIP1) by TGF-beta were detected in all HCC cell lines, implying that the molecular integrity of the TGF-beta receptors might be intact. The amplification and overexpression of cyclin D1 gene was detected in 4 (50%) of 8 HCC cells that showed resistance to TGF-beta1. The suppression of cyclin D1 expression with antisense cyclin D1 facilitated the TGF-beta1-triggered growth inhibition in a TGF-beta1 resistant HCC cell line containing amplified cyclin D1 gene. In conclusion, the overexpression of cyclin D1 may be responsible for the attenuation of TGF-beta1 induced growth inhibition in some HCC cells. (C) 2002 Elsevier Science (USA). | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Academic Press | - |
dc.title | Attenuation of transforming growth factor beta-induced growth inhibition in human hepatocellular carcinoma cell lines by cyclin D1 overexpression | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 방영주 | - |
dc.identifier.doi | 10.1006/bbrc.2002.6666 | - |
dc.citation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.wosid | 000174793200014 | - |
dc.identifier.scopusid | 2-s2.0-0036291169 | - |
dc.citation.endpage | 389 | - |
dc.citation.number | 2 | - |
dc.citation.startpage | 383 | - |
dc.citation.volume | 292 | - |
dc.identifier.sci | 000174793200014 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Kim, Tae You | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MAMMARY EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | HUMAN GASTRIC-CANCER | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | II RECEPTOR | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | GENE MUTATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ANTISENSE | - |
dc.subject.keywordPlus | ARREST | - |
dc.subject.keywordPlus | AMPLIFICATION | - |
dc.subject.keywordAuthor | transforming growth factor-beta (TGF-beta) | - |
dc.subject.keywordAuthor | hepatocellular carcinoma (HCC) | - |
dc.subject.keywordAuthor | growth inhibition | - |
dc.subject.keywordAuthor | carcinogenesis | - |
dc.subject.keywordAuthor | G1 cyclin | - |
dc.subject.keywordAuthor | antisense | - |
dc.subject.keywordAuthor | cell cycle | - |
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