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Integrated Electrochemical Sensors and Actuators for Multifunctional Surgical Endoscope and Glucose Monitoring System : 다기능성 수술용 내시경과 당 모니터링 시스템을 위한 집적된 전기화학적 센서와 엑추에이터 시스템 구현
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 현택환 | - |
dc.contributor.author | 이현재 | - |
dc.date.accessioned | 2017-07-13T08:44:15Z | - |
dc.date.available | 2017-10-23T07:46:29Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000136055 | - |
dc.identifier.uri | https://hdl.handle.net/10371/119797 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 화학생물공학부, 2016. 8. 현택환. | - |
dc.description.abstract | Over the past decade, flexible and stretchable electronics have achieved remarkable progress with regard to materials, designs, and manufacturing processes for biomedical applications. The electronics resolve the intrinsic mechanical mismatch between the devices and soft/curvilinear biological substrates. This enables a wide range of applications in noninvasive, minimally invasive, and wearable devices. This dissertation includes two examples of multifunctional, flexible, and stretchable electronic systems for biomedical applications, especially in dealing with colon cancer and diabetes.
First, the multifunctional endoscope system is introduced as a minimally invasive surgical tool for colon cancer treatment. Transparent bioelectronics based on a graphene hybrid are fabricated for impedance- and pH-based colon cancer detection. Bioelectronics can ablate colon cancer by using radio frequency as a feedback therapy. The bioelectronics placed in the endoscope can provide both characterization and treatment of colon cancer without optical hindrance. Second, wearable and/or disposable sweat monitoring devices with microneedle-based transdermal drug delivery devices are developed for noninvasive blood glucose control. The glucose in sweat is correlated with the glucose in blood, which enables sweat-based blood glucose monitoring. The sensors monitor the sweat glucose concentration with a correction based on pH, temperature, and humidity measurements for accurate sensing. A thermoresponsive microneedle with drug loading is integrated for controlled transdermal drug delivery when hypoglycemia occurs. The dissertation herein provides two representative examples of a multifunctional system as the basis for a closed-loop solution from disease monitoring to treatment. In-vitro, ex-vivo, and in-vivo experiments highlight the utility of the demonstrated technologies for colon cancer and diabetes treatment. | - |
dc.description.tableofcontents | Chapter 1. Recent advances in flexible and stretchable bio-electronic devices 1
1.1 Introduction 1 1.2 Bio-integrated flexible and stretchable system 3 1.3 Flexible and stretchable bioelectronics systems 7 1.4 Conclusion 20 References 21 Chapter 2. An endoscope with integrated transparent bioelectronics for colon cancer treatment 28 2.1 Introduction 28 2.2 Experimental Section 31 2.3 Result and Discussion 37 2.4 Conclusion 69 References 70 Chapter 3. A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy 73 3.1 Introduction 73 3.2 Experimental Section 76 3.3 Result and Discussion 86 3.4 Conclusion 129 References 131 Chapter 4. Wearable/disposable sweat glucose monitor for non-invasive blood glucose monitoring 137 4.1 Introduction 137 4.2 Experimental Section 140 4.3 Result and Discussion 147 4.4 Conclusion 175 References 176 국문 초록 (Abstract in Korean) 181 | - |
dc.format | application/pdf | - |
dc.format.extent | 7712659 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Flexible electronics | - |
dc.subject | Stretchable electronics | - |
dc.subject | Wearable electronics | - |
dc.subject | Electrochemical sensors | - |
dc.subject | Endoscope | - |
dc.subject | Glucose monitoring system | - |
dc.subject.ddc | 660 | - |
dc.title | Integrated Electrochemical Sensors and Actuators for Multifunctional Surgical Endoscope and Glucose Monitoring System | - |
dc.title.alternative | 다기능성 수술용 내시경과 당 모니터링 시스템을 위한 집적된 전기화학적 센서와 엑추에이터 시스템 구현 | - |
dc.type | Thesis | - |
dc.description.degree | Doctor | - |
dc.citation.pages | xiii, 174 | - |
dc.contributor.affiliation | 공과대학 화학생물공학부 | - |
dc.date.awarded | 2016-08 | - |
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