Fabrication of functionalized SiO₂/TiO₂ hollow nanoparticles for drug delivery and neuronal development applications

Abstract

In recent years, to incorporate diverse components into a single nanoscale system have been a great deal of interest in biomedical fields. These hybrid nanomaterials provide multifunctionality and the extraordinarily enhanced performance than bulk sized material- or single component nanomaterial-based application. Therefore, with advancing in nanotechnology, many efforts have been also paid to the fabrication of hybrid materials. Nanoparticle is the basic structure to achieve such hybridiziation. Additionally, nanoparticle is the most internalized structure in the cells compared to other nanostructures. However, there is still lack of literature about fabrication of hybrid nanoparticles for biomedical applications. The dissertation describes the fabricating multifunctional hybrid nanoparticles, evaluating their cytotoxicity, and applying them into neuronal development promoter, stimuli responsive anticancer therapy. This dissertation describes the different ways in the synthetic methology of hybrid nanoparticles. First, GO enwrapped HNPs were fabricated for PpIX loading agent and employed for PDT and PTT agent. In case of both of NIR and visible light irradiation condition, the PTT and PDT synergic therapeutic effect has been attained. Second, Mg-HNP, Ca-HNP, Sr-HNP, and Ba-HNPs were used to encapsulating agent for nerve growth factor and further applied as neuronal differentiation enhancer. Sr-HNPs were exceptionally efficient for promoting neuronal development cooperated with nerve growth factor. Third, a stimuli-responsive GQD/PPy-HNPs were synthesized for use as a bio imaging and drug delivery agent. Each hybrid nanoparticles are intentionally designed and customized of superior performance in specific performance. This dissertation provides the possibility of various approaches for the preparation of multifunctional hybrid nanoparticles and their biomedical applications. The hybrid nanoparticles presented in the dissertiation could be applied into biomedical fields such as neuronal development promoter, enhanced phototherapy agent, bioimaging probe, and controlled drug release system. This study might provide understanding of fabricating hybrid nanoparticles with multifunctionality and application of hybrid nanoparticles to biomedical application.