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The Protective Effect of Systemic Steroid Administration in Hearing Preservation after Cochlear Implantation in Guinea Pigs
기니픽 동물 모델에서 전신적 스테로이드 투여의 와우 이식 후 청력 보존 효과에 대한 고찰

DC Field Value Language
dc.contributor.advisor이준호-
dc.contributor.author나윤찬-
dc.date.accessioned2017-07-14T01:39:44Z-
dc.date.available2017-07-14T01:39:44Z-
dc.date.issued2017-02-
dc.identifier.other000000141554-
dc.identifier.urihttp://hdl.handle.net/10371/122218-
dc.description학위논문 (박사)-- 서울대학교 대학원 : 의학과, 2017. 2. 이준호.-
dc.description.abstractObjectives: To determine the effectiveness of extended delivery of systemic steroids to preserve hearing in guinea pigs after cochlear implantation (CI).

Methods: Dexamethasone (4 mg/ml) was delivered parenterally via a mini-osmotic pump for either 3 or 7 days. The control group underwent CI without steroid infusion. A dummy CI electrode was inserted via a cochleostomy approach in 8-week-old guinea pigs. Auditory thresholds were assessed from tone burst auditory brainstem responses (2, 8, 16, 24, and 32 kHz) at 1 day prior to CI and 1, 4, and 12 weeks after implantation. Histologic evaluation of the cochleae was carried out.

Results: No differences were found in hearing thresholds among groups before CI. Significant hearing preservation was achieved at 8, 16, 24, and 32 kHz only in the 7-day infusion group compared with the control group at 1 week after CI. The same trend was maintained at 4 weeks (16, 24 kHz) and 12 weeks (16, 24, and 32 kHz). Histologic review of the 7-day infusion group revealed less loose connective tissue deposition, less dense fibrosis in the scala tympani and the preservation of more spiral ganglion cells, compared with the control group.

Conclusion: Seven-day administration of systemic steroids was more effective in preserving residual hearing for 12 weeks after cochlear implantation (CI) than a 3-day delivery.
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dc.description.tableofcontentsIntroduction 1
Material and Methods 3
Experimental animals and group allocation 3
Steroid infusion and cochlear implantation 4
Auditory threshold measurement 5
Histology 6
Statistical analysis 7
Results 9
Hearing changes 9
Histologic changes 10
Discussion 14
Conclusion 19
References 20
국문초록 39
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dc.formatapplication/pdf-
dc.format.extent1126094 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectCochlear implant-
dc.subjectHearing loss-
dc.subjectSteroid-
dc.subject.ddc610-
dc.titleThe Protective Effect of Systemic Steroid Administration in Hearing Preservation after Cochlear Implantation in Guinea Pigs-
dc.title.alternative기니픽 동물 모델에서 전신적 스테로이드 투여의 와우 이식 후 청력 보존 효과에 대한 고찰-
dc.typeThesis-
dc.contributor.AlternativeAuthorYoon Chan Rah-
dc.description.degreeDoctor-
dc.citation.pagesiv, 40-
dc.contributor.affiliation의과대학 의학과-
dc.date.awarded2017-02-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Medicine (의학과)Theses (Ph.D. / Sc.D._의학과)
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