Publications
Detailed Information
The study on the oxidation of DNA-Silver nanodots and its application : DNA에 둘러싸인 은 나노닷의 산화 특성에 대한 연구 및 적용
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Yu Junhua | - |
dc.contributor.author | 박순영 | - |
dc.date.accessioned | 2017-07-19T02:58:00Z | - |
dc.date.available | 2017-07-19T02:58:00Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.other | 000000022297 | - |
dc.identifier.uri | https://hdl.handle.net/10371/128036 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 과학교육과, 2014. 8. Yu Junhua. | - |
dc.description.abstract | Fluorescence has been progressively adapted toward in vivo molecular imaging recently because of their high sensitivity and selectivity, which make it possible to detect target at single molecule level with a high temporal resolution, in optimized system. To achieve efficacy of fluorescence imaging, a proper fluorescence probe is essential. ssDNA encapsulated Ag NDs are most attractive emerging fluorophores, because of their excellent photophysical properties and reasonable biocompatibility. However accurate structures and synthetic mechanisms of DNA-Ag NDs are still not clear. Therefore analyzing the response of DNA-Ag NDs in the process of oxidation gives us better understanding of DNA-Ag NDs. We examined the oxidation process of NDs by using red emissive DNA-Ag ND molecules in the presence of various reactive oxygen species. In addition, with discovered oxidative properties, we have developed ratiometric luminescence probes and new form of imaging process. | - |
dc.description.tableofcontents | Contents
I. Introduction 1.1. Molecular imaging 1.1.1. What is the molecular imaging? 1.1.2. PET (Positron Emission Tomography). 1.1.3. Optical imaging . 1.1.3.1. Strategies of optical imaging 1.2. Fluorophores 1.2.1. Photoluminescence 1.2.1.1. Basic principles of photoluminescence 1.2.1.2. Fluorescence and phosphorescence 1.2.2. What is good fluorophore? 1.2.2.1. Fluorophores. 1.2.2.2. Required photo physical properties of good fluorophore 1.2.3. Widely used fluorophores 1.2.3.1. Organic fluorophores 1.2.3.2. Quantum dots 1.3. DNA encapsulated silver nanodots 1.3.1. Advantages of DNA-Ag NDs 1.3.2. Undisclosed DNA-Ag NDs emission mechanism 1.4. What happens in oxidation of DNA-Ag NDs 1.4.1. Oxidation of DNA-Ag NDs 1.4.2. Applications of oxidative DNA-Ag NDs for specific probe II. Experimental section 2.1. Chemicals 2.2. Preparation and measurement of samples III. Results and discussion 3.1. Oxidation properties of DNA-Ag NDs 3.2. Ratiometric luminescence probe for hypochlorite detection 3.3. Oxidant-resistant imaging by coupling with GOx 35 IV. Conclusions 37 V. References 39 국문초록 48 | - |
dc.format | application/pdf | - |
dc.format.extent | 1403768 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | DNA | - |
dc.subject | Ag NDs | - |
dc.subject | Ratiometric | - |
dc.subject | Hydrogen peroxide | - |
dc.subject | Hypochlorite | - |
dc.subject | Glucose oxidase | - |
dc.subject.ddc | 507 | - |
dc.title | The study on the oxidation of DNA-Silver nanodots and its application | - |
dc.title.alternative | DNA에 둘러싸인 은 나노닷의 산화 특성에 대한 연구 및 적용 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | vii, 49 | - |
dc.contributor.affiliation | 사범대학 과학교육과 | - |
dc.date.awarded | 2014-08 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.