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Enhanced antimicrobial activity of silver/polyrhodanine composite decorated silica nanoparticle : 은/폴리로다닌 복합체를 함유한 실리카 나노입자의 항균 증진 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 장정식 | - |
dc.contributor.author | 김현영 | - |
dc.date.accessioned | 2017-07-19T06:00:22Z | - |
dc.date.available | 2017-07-19T06:00:22Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.other | 000000008512 | - |
dc.identifier.uri | https://hdl.handle.net/10371/129463 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 화학생물공학부, 2013. 2. 장정식. | - |
dc.description.abstract | This work describes the novel solution system synthesis of silver/polyrhodanine composite decorated silica NPs. Polymerization of polyrhodanine proceeded preferentially on the surface of the silica NPs where the Ag+ ion was located. During the polymerization, the embedded Ag+ ions reduced to metallic Ag NPs and consequentially silver/polyrhodanine composite NPs (ca. 7 nm) were formed on the surface of the silica nanoparticle. The existence of silver NPs and polyrhodanine on the silica NPs were verified through microscopic observation, FTIR, UV-vis, and XRS analysis. The composite nanoparticle decorated silica NPs exhibited excellent antimicrobial activities against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Importantly, the synthesized composite NPs retained antimicrobial activity under silver depletion condition due to the contact-active biocidal polyrhodanine. Therefore, it can be anticipated that the silver/polyrhodanine composite decorated silica NPs have potential for use as a long-term antimicrobial agent. | - |
dc.description.tableofcontents | Chapter 1. Introduction 1
1.1 Background of antimicrobial field 1 1.2 Antimicrobial nanomaterials 2 1.2.1 Silver nanoparticles 2 1.2.2 Antimicrobial polymer nanomaterials 3 1.3 Metal/polymer nanocomposites 4 1.3.1 Antimicrobial silver-polymer nanocomposite 4 1.3.2 Preparation strategies 5 1.4 Objective of this study 7 Chapter 2. Experimental 8 2.1 Materials 8 2.2 Fabrication of silver/polyrhodanine composite decorated silica nanoparticles 9 2.3 Fabrication of silver decorated silica NPs 10 2.4 Antimicrobial test 10 2.5 FE-SEM observation of bacteria 11 2.6 Antimicrobial test under silver depletion condition 12 2.7 Characterization 13 Chapter 3. Results and discussion 14 3.1 Fabrication of SiO2-Ag/PRh NPs 14 3.2 Characterization of SiO2-Ag/PRh NPs 15 3.2.1 Microscopic analysis 15 3.2.2 XPS analysis 19 3.2.3 FTIR and UV-vis analysis 21 3.2.4 Synthetic mechanism of SiO2-Ag/PRh NPs 28 3.3 Antimicrobial activity of SiO2-Ag/PRh NPs 30 3.3.1 Antimicrobial activity of SiO2-Ag/PRh NPs 30 3.3.2 Antimicrobial test under silver depletion condition 34 Chapter 4. Conclusion 38 References 39 국문요약 43 | - |
dc.format | application/pdf | - |
dc.format.extent | 2563420 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | silver nanoparticle | - |
dc.subject | polyrhodanine | - |
dc.subject | nanocomposite | - |
dc.subject | oxidation polymerization | - |
dc.subject | bactericidal | - |
dc.subject.ddc | 660 | - |
dc.title | Enhanced antimicrobial activity of silver/polyrhodanine composite decorated silica nanoparticle | - |
dc.title.alternative | 은/폴리로다닌 복합체를 함유한 실리카 나노입자의 항균 증진 효과 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Hyunyoung Kim | - |
dc.description.degree | Master | - |
dc.citation.pages | 43 | - |
dc.contributor.affiliation | 공과대학 화학생물공학부(에너지환경 화학융합기술전공) | - |
dc.date.awarded | 2013-02 | - |
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