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Chronic pain induced structural reorganization of spines in the anterior cingulate cortex : Anterior cingulate cortex에서 일어나는 만성 통증에 의한 시냅스 가시의 구조적인 재편성
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 강봉균 | - |
dc.contributor.author | 최태혁 | - |
dc.date.accessioned | 2017-07-19T08:39:56Z | - |
dc.date.available | 2017-07-19T08:39:56Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000136412 | - |
dc.identifier.uri | https://hdl.handle.net/10371/131215 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 협동과정 뇌과학전공, 2016. 8. 강봉균. | - |
dc.description.abstract | Anterior cingulate cortex (ACC) has known to be involved in pain processing. Changes in spine number and morphology are some of the critical events during long-term synaptic plasticity. We induced chronic pain by neuropathic pain surgery and analyzed the change of dendritic spines after imaging single neuron in z-stack. Spine volumes, head diameters and straightness which reflected the overall structures of spines were not altered by chronic pain. Many other parameters of spines were also not altered by chronic pain, but only spine length, especially spine neck length decreased by chronic pain. Anisomycin treatment blocked chronic pain induced morphological changes of spines. From these results, we could conclude that chronic pain signal induced by nerve ligation in hind limb evoked structural plasticity of spines only in a minor level and it was related with protein synthesis. | - |
dc.description.tableofcontents | Introduction 4
Anterior cingulate cortex (ACC) functions and structures 4 Chronic pain animal model 5 Spine structures 5 Morphological development of spines 7 Synaptic activity-dependent structural plasticity 8 Structural plasticity of spines Associated with Long-Term Potentiation 8 Methods 10 Results 13 Dendritic spines stimulated by chronic pain were analyzed 13 Overall structures of spines were not altered by chronic pain 13 Spine neck length was altered by chronic pain 14 Spine head diameters were fluctuating based on measurement criterion 15 Mean spine head diameter was not altered by chronic pain 15 Figures 17 Discussion 29 References 31 국문 초록 40 | - |
dc.format | application/pdf | - |
dc.format.extent | 794941 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Anterior cingulate cortex | - |
dc.subject | chronic pain | - |
dc.subject | spine | - |
dc.subject | structural plasticity | - |
dc.subject | protein synthesis | - |
dc.subject | Imaris | - |
dc.subject | synaptic activity | - |
dc.subject.ddc | 611 | - |
dc.title | Chronic pain induced structural reorganization of spines in the anterior cingulate cortex | - |
dc.title.alternative | Anterior cingulate cortex에서 일어나는 만성 통증에 의한 시냅스 가시의 구조적인 재편성 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 41 | - |
dc.contributor.affiliation | 자연과학대학 협동과정뇌과학전공 | - |
dc.date.awarded | 2016-08 | - |
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