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Identification of Secondary Metabolites from Marine Organism Associated Fungi
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 강헌중 | - |
dc.contributor.author | 성유정 | - |
dc.date.accessioned | 2017-07-19T08:55:36Z | - |
dc.date.available | 2017-07-19T08:55:36Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.other | 000000136431 | - |
dc.identifier.uri | https://hdl.handle.net/10371/131425 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 지구환경과학부, 2016. 8. 강헌중. | - |
dc.description.abstract | Marine fungi have been the subject of extensive chemical and biological investigations in the last several decades. A large number of marine fungi have been isolated from various marine sources which include mangroves, sponges, algae and marine sediments, increasing in the order of numbers of strains isolated.
In our research, we collected several sponges from Guggul-island, Korea and isolated some marine fungi from the cortex and core part of those sponges. From them, we conducted screening on five fungi species and chose one fungus strain for further study. Two new compounds and two known compounds, Ambuic acid and its derivatives, were isolated from Colletotrichum gloeosporioides strain. Compounds were evaluated for antibacterial activity by the 2-fold microtiter broth dilution method, but they did not display significant antibacterial activity. On the other hand, they displayed anti-inflammatory activity that inhibits nitric oxide production from RAW 264.7 macrophage cells over 50 μM. Also, research on three fungi strains isolated from Halocynthia roretzi was conducted. Among them, we focused on Aphanocladium sp. NW570b. One compound was isolated, but structure elucidation is on progress. Structure elucidation of all the compounds isolated was performed by analysis of LC-MS and NMR data (1H, 13C, COSY, HMBC and HSQC). | - |
dc.description.tableofcontents | Chapter 1 General Introduction of Marine Natural Products 1
1.1 Transition of Researches on Discovery of Marine Natural Products 1 1.2 Bioactive Potential of Fungal Secondary Metabolites 3 Chapter 2 Ambuic-acid Derivatives from Marine Fungus Colletotrichum gloeosporides 6 2.1 Introduction 6 2.2 Results & Discussion 8 2.2.1 Structure Elucidation 8 2.2.2 Biological Activities 17 2.3 Experimental Section 19 2.3.1 Instruments and Data Collection 19 2.3.2 Fungal Strain 20 2.3.3 Cultivation, Extraction and Isolation 22 2.3.4 Bioassays 23 Chapter 3 F15C004-6 A from Aphanocladium sp. NW570b 25 3.1 Introduction 25 3.2 Result and discussion 26 3.2.1 Structure Elucidation 26 3.2.2 Biological Activities 30 3.3 Experimental Section 32 3.3.1 Instruments and data collection 32 3.3.2 Isolation and cultivation of Fungus from sponge 33 3.3.3 Extraction and Isolation 35 3.3.4 Bioassays 36 Appendix 40 국문 초록 69 | - |
dc.format | application/pdf | - |
dc.format.extent | 2923592 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Marine natural products | - |
dc.subject | Secondary metabolites | - |
dc.subject | Marine fungi | - |
dc.subject | Colletotrichum gloeosporioides | - |
dc.subject | Aphanocladium sp. | - |
dc.subject.ddc | 550 | - |
dc.title | Identification of Secondary Metabolites from Marine Organism Associated Fungi | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.citation.pages | 69 | - |
dc.contributor.affiliation | 자연과학대학 지구환경과학부 | - |
dc.date.awarded | 2016-08 | - |
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