Publications
Detailed Information
Comparison of genomic characteristics of synchronous intracranial meningiomas of different histological grade : 서로 다른 조직학적 단계의 동시성 뇌수막종의 유전체 변이 특성 비교
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이상형 | - |
dc.contributor.author | Tamrin Chowdhury | - |
dc.date.accessioned | 2017-07-19T10:35:47Z | - |
dc.date.available | 2017-07-19T10:35:47Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.other | 000000140746 | - |
dc.identifier.uri | https://hdl.handle.net/10371/132907 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2017. 2. 이상형. | - |
dc.description.abstract | Meningioma is the most common tumor of the central nervous system. Although several genetic studies of meningioma reveals various significant mutation related to meningioma development but still further studies are needed for confirming specific mutations. Here whole exome study was done on two meningioma samples of different histological grade obtained from a patient with multiple meningioma. This study shows that the each meningioma shows distinct tumor mutation despite from the same patient. Also both the meningioma shows distinct separate relations with different pathways. The common genetic abnormal incidence was the loss of Heterozygosity of the chromosome 22 in both tumors which maybe the cause of the tumor development and the subsequent mutations plays a role in progression towards different grades. | - |
dc.description.tableofcontents | Chapter 1. Introduction 1
1.1 Study Background 1 1.2. Purpose of Research 2 Chapter 2. Materials and Methods 3 2.1 Case History 3 2.2 Sample Collection 9 2.3 Whole Exome Sequencing 9 2.4 RNA Sequencing 10 2.5 Processing of Sequenced Data 10 Chapter 3. Results 12 3.1 Quality Control Assessment and Tumor Purity analysis 12 3.2 No common gene mutations between synchronous meningiomas 14 3.3. Common genetic event of Loss of heterozygosity in 22 in synchronous meningiomas 19 3.4 Differential gene expression analysis 21 3.5 Hypothesis of genomic evolution process of meningioma development and progression 32 Chapter 4. Discussion 35 Chapter 5. Conclusion 39 Abstract in Korean 43 | - |
dc.format | application/pdf | - |
dc.format.extent | 3139912 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Neurosurgery | - |
dc.subject | Meningioma | - |
dc.subject.ddc | 610 | - |
dc.title | Comparison of genomic characteristics of synchronous intracranial meningiomas of different histological grade | - |
dc.title.alternative | 서로 다른 조직학적 단계의 동시성 뇌수막종의 유전체 변이 특성 비교 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | 탐린 | - |
dc.description.degree | Master | - |
dc.citation.pages | 53 | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2017-02 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.