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Design and Synthesis of a Sphingoid Base Library : 스핑고리피드 라이브러리의 설계와 합성
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Sanghee Kim | - |
dc.contributor.author | Woo-Jung Kim | - |
dc.date.accessioned | 2017-07-19T11:22:49Z | - |
dc.date.available | 2019-04-18 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.other | 000000132388 | - |
dc.identifier.uri | https://hdl.handle.net/10371/133615 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과, 2016. 2. 김상희. | - |
dc.description.abstract | Sphingolipids have been found to be important signaling molecules in a wide variety of biological pathways, in particular inflammation and cancer. The basic sphingolipid structure consists of three parts | - |
dc.description.abstract | a lipid chain, a linker, and a polar head group. These parts can be modified one-by-one or in combination to further elucidate the role of sphingolipids, as well as to develop and identify promising new leads in this class of compounds. Herein we report the design and synthesis of sphingolipid analogues with modifications to the linker and polar head components of the typical sphingolipid scaffold. Various pathways and synthetic routes were utilized. Through [2+3] cycloaddition and the variation of chain lengths, various library compounds were designed and synthesized. | - |
dc.description.tableofcontents | I. Introduction 1
II. Results and Discussion 3 II.1. Design of Library Compounds: 3 II.2. Construction of Library Compounds: 4 II.2.1. Preparation of substrate: 4 II.2.2. Library Compound Series 1 Syntheses: 6 II.2.3. Library Compound Series 2 Syntheses: 8 III. Conclusion 10 IV. Experimental 11 V. References 19 VI. Spectra 20 VII. Abstract in Korean 37 | - |
dc.format | application/pdf | - |
dc.format.extent | 1643057 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Sphingolipid | - |
dc.subject | Cycloaddition | - |
dc.subject | Diversity-Orientated | - |
dc.subject | Library Construction | - |
dc.subject.ddc | 615 | - |
dc.title | Design and Synthesis of a Sphingoid Base Library | - |
dc.title.alternative | 스핑고리피드 라이브러리의 설계와 합성 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | 김우정 | - |
dc.description.degree | Master | - |
dc.citation.pages | 41 | - |
dc.contributor.affiliation | 약학대학 약학과 | - |
dc.date.awarded | 2016-02 | - |
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