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Stereoselective Synthesis of D-5-Homo-4-selenonucleosides as Potent Therapeutic Agents : 효과적인 치료제로서의 D-5-Homo-4-selenonucleosides의 입체 선택적 합성

DC Field Value Language
dc.contributor.advisor정낙신-
dc.contributor.author최유진-
dc.date.accessioned2017-07-19T11:23:45Z-
dc.date.available2017-07-19T11:23:45Z-
dc.date.issued2016-02-
dc.identifier.other000000133435-
dc.identifier.urihttps://hdl.handle.net/10371/133627-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 약학대학 약학과 약품화학전공, 2016. 2. 정낙신.-
dc.description.abstractD-5-Homo-4-selenonucleosides were synthesized from D-5-homo-4-selenoribose using a Pummerer-type condensation. For the stereoselective synthesis of the key intermediate D-5-homo-4-selenoribose, we employed Sharpless asymmetric epoxidation, regioselective epoxide cleavage, and stereoselective reduction of the ketone as the key steps.-
dc.description.tableofcontentsI.Introduction 2

II.Results and Discussion 6
1.Retrosynthetic Plan 6
2.Synthesis 7

III.Conclusion 15

IV.Experimental Section 16
1.General Procedures 16
2.Experimental Procedures 17

V.References 40

국문초록 43		-
dc.formatapplication/pdf-
dc.format.extent1279125 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectD-5’-Homo-4’-selenonucleosides-
dc.subjectSharpless asymmetric epoxidation-
dc.subjectRegioselective cleavage-
dc.subjectStereoselective reduction-
dc.subject.ddc615-
dc.titleStereoselective Synthesis of D-5-Homo-4-selenonucleosides as Potent Therapeutic Agents-
dc.title.alternative효과적인 치료제로서의 D-5-Homo-4-selenonucleosides의 입체 선택적 합성-
dc.typeThesis-
dc.description.degreeMaster-
dc.citation.pages43-
dc.contributor.affiliation약학대학 약학과-
dc.date.awarded2016-02-
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