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MuSK antibody-positive, seronegative myasthenia gravis in Korea

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Authors
Lee, Jee-Young; Sung, Jung Joon; Cho, Joong-Yang; Oh, Dong-Hoon; Kim, Hyun-Jung; Park, Jong-Ha; Lee, Kwang Woo; Choi, Young-Chul; Vincent, Angela
Issue Date
2006-03-21
Publisher
Elsevier
Citation
J Clin Neurosci. 2006 Apr;13(3):353-5. Epub 2006 Mar 20.
Keywords
AdolescentAdultAge of OnsetAntibodies/*bloodChildChild, PreschoolFemaleHumansImmunosuppressive Agents/pharmacologyInfantKorea/epidemiologyMaleMiddle AgedMyasthenia Gravis/*blood/*immunology/therapyReceptor Protein-Tyrosine Kinases/*immunologyReceptors, Cholinergic/*immunologySeverity of Illness IndexThymectomy/methods
Abstract
Several reports from Western countries suggest differences in the clinical features of patients with muscle specific kinase (MuSK) antibody-positive and -negative seronegative myasthenia gravis (MG). We performed the first survey in Korea of MuSK antibodies, studying 23 patients with acetylcholine receptor (AChR)-antibody seronegative MG. MuSK antibodies were present in 4 (26.7%) of 15 generalized seronegative MG patients and none of 8 ocular seronegative MG patients. All four MuSK positive patients were females, with pharyngeal and respiratory muscle weakness, and required immunosuppressive treatment. However, overall disease severity and age at onset was similar to that of MuSK-negative MG and treatment responses were equally good.
ISSN
0967-5868 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHP-4JHMXX2-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=13ad3a069651af3cf0ad687e4e737f69

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16546389

http://hdl.handle.net/10371/13464
DOI
https://doi.org/10.1016/j.jocn.2005.04.028
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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