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Rhodium-Catalyzed Oxygenative Addition of Alcohols and Amines to Terminal Alkynes for the Synthesis of Esters and Amides : 말단 알카인의 알코올 및 아민과의 산화적 로듐촉매 첨가반응을 통한 에스터와 아마이드 합성
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- Authors
- Advisor
- 이철범
- Major
- 자연과학대학 화학부
- Issue Date
- 2013-02
- Publisher
- 서울대학교 대학원
- Keywords
- Rhodium vinylidenes ; Metallo ketene ; Ester synthesis ; Amide synthesis ; Oxygenative addition
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 화학부 유기화학 전공, 2013. 2. 이철범.
- Abstract
- A rhodium-catalyzed reaction has been developed, in which terminal alkynes undergo an oxygenative addition with alcohols and amines to produce the corresponding esters and amides as the products. In this process, the rhodium vinylidene generated from a terminal alkyne is converted to a rhodium ketene complex by oxygen transfer from sulfoxides or N-oxides. Subsequently, the addition of nucleophiles such as alcohols and amines to the ketene complex gives esters and amides.
Mechanistic studies suggest that the catalytic reaction involves the formation of a rhodium ketene complex via the oxidation of the metal-bound unsaturated carbene.
- Language
- English
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