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Functional connection between two oncogenic proteins, K-Ras and AIMP2-DX2
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 김성훈 | - |
dc.contributor.author | 송재하 | - |
dc.date.accessioned | 2017-10-31T08:20:52Z | - |
dc.date.available | 2020-02-03T23:58:28Z | - |
dc.date.issued | 2017-08 | - |
dc.identifier.other | 000000145217 | - |
dc.identifier.uri | https://hdl.handle.net/10371/137947 | - |
dc.description | 학위논문 (석사)-- 서울대학교 융합과학기술대학원 분자의학 및 바이오제약학과, 2017. 8. 김성훈. | - |
dc.description.abstract | K-Ras is the most famous oncogene that is frequently mutated in human cancers, and it influences on poor prognosis with low survival rate of cancer patients. Although K-Ras is a strong target of cancer therapeutics, the mechanism underlying pathological increase of K-Ras is unclear. Here we report that AIMP2-DX2, oncogenic splicing variant of AIMP2-F, is critical determinant of K-Ras stabilization. Through transcriptome analysis in AIMP2-DX2 high- and low-expressing lung cancer cells, we identified AIMP2-DX2 is positively correlated with Ras signaling. In AIMP2-DX2-inducible in vitro and in vivo model, we monitored the stabilization of K-Ras by induction of AIMP2-DX2. AIMP2-DX2 GST-N domain binds to the positively charged hypervariable region of K-Ras and inhibits the β-TrCP-, E3 ligase of K-Ras, mediated ubiquitination. Therefore, this work unveiled that the stabilization of K-Ras can be determined by interaction with AIMP2-DX2 and suggested that the interaction of two oncogenic proteins leads to pathologically synergic cancer-promoting property. | - |
dc.description.tableofcontents | Introduction 1
Results 5 Discussion 12 List of figures and tables 15 Material and methods 28 국문초록 34 References 35 | - |
dc.format | application/pdf | - |
dc.format.extent | 1528394 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 융합과학기술대학원 | - |
dc.subject | K-Ras | - |
dc.subject | AIMP2-DX2 | - |
dc.subject | Oncogene | - |
dc.subject.ddc | 610.28 | - |
dc.title | Functional connection between two oncogenic proteins, K-Ras and AIMP2-DX2 | - |
dc.type | Thesis | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 융합과학기술대학원 분자의학 및 바이오제약학과 | - |
dc.date.awarded | 2017-08 | - |
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