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Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Nam-Kyung | - |
dc.contributor.author | Uhm, Heesoo | - |
dc.contributor.author | Shim, Jaehoon | - |
dc.contributor.author | Choi, Jun-Hyeok | - |
dc.contributor.author | Bae, Sangsu | - |
dc.contributor.author | Sacktor, Todd Charlton | - |
dc.contributor.author | Hohng, Sungchul | - |
dc.contributor.author | Kaang, Bong-Kiun | - |
dc.date.accessioned | 2017-12-12T00:26:57Z | - |
dc.date.available | 2017-12-12T09:28:40Z | - |
dc.date.issued | 2017-11-29 | - |
dc.identifier.citation | Molecular Brain, 10(1):56 | ko_KR |
dc.identifier.issn | 1756-6606 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138440 | - |
dc.description.abstract | Abstract
Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhances long-term memory and LTP. Thus, multiple lines of evidence suggest a significant role for persistently elevated PKMζ levels in long-term memory. The molecular mechanisms of how synaptic properties are regulated by the increase in PKMζ, however, are still largely unknown. The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor (AMPAR) mediates most of the fast glutamatergic synaptic transmission in the brain and is known to be critical for the expression of synaptic plasticity and memory. Importance of AMPAR trafficking has been implicated in PKMζ-mediated cellular processes, but the detailed mechanisms, particularly in terms of regulation of AMPAR lateral movement, are not well understood. In the current study, using a single-molecule live imaging technique, we report that the overexpression of PKMζ in hippocampal neurons immobilized GluA2-containing AMPARs, highlighting a potential novel mechanism by which PKMζ may regulate memory and synaptic plasticity. | ko_KR |
dc.description.sponsorship | This work was supported by a Creative Research Initiative grant (Physical Genetics Laboratory, 2009–0081562), which was awarded to S.H., and by a National Honor Scientist Program award to B.-K.K. (NRF2012R1A3A1050385) from the National Research Foundation of Korea, and 2R37MH057068 and
R01 DA034970 to T.C.S. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | PKMζ | ko_KR |
dc.subject | PKM-zeta | ko_KR |
dc.subject | AMPAR | ko_KR |
dc.subject | Quantum dots | ko_KR |
dc.subject | Single molecule imaging | ko_KR |
dc.subject | GluA2 | ko_KR |
dc.subject | LTP | ko_KR |
dc.subject | Lateral diffusion | ko_KR |
dc.title | Increased PKMζ activity impedes lateral movement of GluA2-containing AMPA receptors | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 유남경 | - |
dc.contributor.AlternativeAuthor | 엄희수 | - |
dc.contributor.AlternativeAuthor | 심재훈 | - |
dc.contributor.AlternativeAuthor | 최준혁 | - |
dc.contributor.AlternativeAuthor | 배상수 | - |
dc.contributor.AlternativeAuthor | 홍성철 | - |
dc.contributor.AlternativeAuthor | 강봉근 | - |
dc.identifier.doi | 10.1186/s13041-017-0334-7 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-12-10T05:00:36Z | - |
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