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Anemia is associated with incidence of dementia: a national health screening study in Korea involving 37,900 persons

Cited 29 time in Web of Science Cited 28 time in Scopus
Authors
Jeong, Su-Min; Shin, Dong Wook; Lee, Ji Eun; Hyeon, Jung Hyeon; Lee, Jinkook; Kim, SangYun
Issue Date
2017-12-06
Publisher
BioMed Central
Citation
Alzheimer's Research & Therapy, 9(1):94
Keywords
AnemiaDementiaSeverity of anemiaICD-10
Abstract
Background
The aim of this study was to investigate whether anemia is associated with dementia incidence in the elderly.

Methods
Using the Korean National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) database, we identified 66-year-old subjects (n = 37,900) who were free of dementia and stroke. Anemia (hemoglobin < 12 g/dl for women and < 13 g/dl for men) and the severity of anemia (mild, moderate, or severe) were defined using World Health Organization criteria. The incidence of dementia was identified using International Classification of Diseases, Tenth Revision, dementia diagnosis codes (F00, F01, F02, F03, and G30) with prescription of an antidementia drug. Cox proportional hazards regression models were used to assess HRs for dementia incidence according to anemia.

Results
After adjusting for sex, baseline cognitive state, body mass index, smoking status, household income, disability, depression, hypertension, diabetes, and dyslipidemia, we found a significant association between anemia and dementia incidence (adjusted HR 1.24; 95% CI 1.02–1.51). The adjusted HRs for incidence of dementia according to the severity of anemia were 1.19 (95% CI 0.98–1.45) for those with mild anemia, 1.47 (95% CI 0.97–2.21) for those with moderate anemia, and 5.72 (95% CI 1.84–17.81) for those with severe anemia, showing a significant p value for trend (p = 0.003).

Conclusions
Anemia is an independent risk factor for dementia incidence, with a marked increase of risk associated with severe anemia.
ISSN
1758-9193
Language
English
URI
http://hdl.handle.net/10371/138441
DOI
https://doi.org/10.1186/s13195-017-0322-2
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College of Medicine/School of Medicine (의과대학/대학원)Family Medicine (가정의학전공)Journal Papers (저널논문_가정의학전공)
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