SHERP

CD34 stromal expression is inversely proportional to the extent of morphea

Cited 0 time in webofscience Cited 0 time in scopus
Authors
Lee, Ji Su; Park, Hyun-sun; Yoon, Hyun-Sun; Cho, Soyun
Issue Date
2017-10-22
Publisher
대한피부과학회
Citation
2017년 제69차 대한피부과학회 추계학술대회, pp. 349-350
Keywords
CD34 stromal expression is inversely proportional to the extent of morphea의약학SclerodermaMorpheaCD34Smooth muscle actinFibrocyte
Abstract
Background: Fibrosis is thought to be the main pathophysiology of scleroderma, and myofibroblasts play a main role in abnormal fibrotic pathologies. Altered distribution of dermal dendrocytes, particularly loss of CD34+ fibrocytes, has been reported in scleroderma. Objective: To investigate the relative expression and distribution of myofibroblast and CD34+ fibrocytes in morphea, we performed immunohistochemical stains using several relevant antibodies. Methods: Skin lesions of 50 patients with morphea and age-, sex- and site-matched normal skin of 50 subjects were evaluated for the following antibodies: SMA, CD34, CD31, and VCAM-1. Results: The patient group showed significantly higher expression of SMA and VCAM-1 stain than the control group (p=0.000 and p=0.027, respectively), while CD34 stromal stain was significantly decreased in the patient group (p=0.000). Within the patient group, CD34 stromal stain had an inverse correlation with SMA and VCAM-1 stains (r=-0.286, p=0.044, and r=-0.296, p=0.037, respectively). In subtype analysis, CD34 stromal expression was lost more in generalized morphea than non-generalized morphea. Limitations: Retrospective nature of the study. Conclusion: Mutually exclusive staining patterns of CD34 stromal and SMA stains suggest a phenotypic change of CD34+ fibrocytes into myofibroblasts with progression of disease in morphea. CD34 may be a useful marker in predicting the extent of morphea.
URI
http://hdl.handle.net/10371/138847
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Others_피부과학전공
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Others_의과학과
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse