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Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen Phuoc Long | - |
dc.contributor.author | Lee, Wun Jun | - |
dc.contributor.author | Nguyen Truong Huy | - |
dc.contributor.author | Lee, Seul Ji | - |
dc.contributor.author | Park, Jeong Hill | - |
dc.contributor.author | Kwon, Sung Won | - |
dc.creator | 박정일 | - |
dc.date.accessioned | 2018-01-24T05:59:31Z | - |
dc.date.available | 2020-04-05T05:59:31Z | - |
dc.date.created | 2017-11-15 | - |
dc.date.issued | 2016-09 | - |
dc.identifier.citation | Cancer Informatics, Vol.15, pp.11-17 | - |
dc.identifier.issn | 1176-9351 | - |
dc.identifier.uri | https://hdl.handle.net/10371/138962 | - |
dc.description.abstract | Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current biomarkers have failed to reach an acceptable level of accuracy for distant metastasis. In this paper, we performed a gene set meta-analysis of in vitro microarray studies and combined the results from this study with previously published proteomic data to validate and suggest prognostic candidates for CRC metastasis. Two microarray data sets included found 21 significant genes. Of these significant genes, ALDOA, IL8 (CXCL8), and PARP4 had strong potential as prognostic candidates. LAMB2, MCM7, CXCL23A, SERPINA3, ABCA3, ALDH3A2, and POLR2I also have potential. Other candidates were more controversial, possibly because of the biologic heterogeneity of tumor cells, which is a major obstacle to predicting metastasis. In conclusion, we demonstrated a meta-analysis approach and successfully suggested ten biomarker candidates for future investigation. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Libertas Academica | - |
dc.title | Novel biomarker candidates for colorectal cancer metastasis: A meta-analysis of in vitro studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.4137/CIN.S40301 | - |
dc.citation.journaltitle | Cancer Informatics | - |
dc.identifier.scopusid | 2-s2.0-84994037011 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201631248 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A001923 | - |
dc.description.srnd | CITE_RATE:0 | - |
dc.description.srnd | DEPT_NM:약학과 | - |
dc.description.srnd | EMAIL:hillpark@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 17 | - |
dc.citation.startpage | 11 | - |
dc.citation.volume | 15 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Jeong Hill | - |
dc.contributor.affiliatedAuthor | Kwon, Sung Won | - |
dc.identifier.srnd | T201631248 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | NUCLEOTIDE EXCISION-REPAIR | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | EXPRESSION PROFILES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA CELLS | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | FUTURE | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | biomarker candidate | - |
dc.subject.keywordAuthor | microarray analysis | - |
dc.subject.keywordAuthor | proteomics | - |
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