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Elucidation of bacterial translation regulatory networks
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Cited 5 time in Scopus
- Authors
- Issue Date
- 2017-04
- Publisher
- Elsevier
- Citation
- Current Opinion in Systems Biology, Vol.2, pp.84-90
- Abstract
- The translational regulatory network of bacteria is governed by diverse interaction between target mRNAs, regulatory RNAs, and cognate proteins. Advances in high-throughput sequencing techniques has helped in understanding the fundamental mechanisms behind translational regulation, including identification of a large number of regulatory small RNAs and antisense RNAs, and genome-wide binding locations of RNA-binding proteins. In this review, different mechanisms of translational regulation are described in the perspective of methods that allow the detection and generation of translational regulatory networks in a genome-wide manner. Furthermore, genome-wide data on translational regulation is the key to fill the gap between transcription and proteins and more importantly, develop more accurate in silico regulatory and metabolic network models. © 2017 Elsevier Ltd.
- ISSN
- 2452-3100
- Language
- English
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