Browse

Clinical factors affecting salivary transferrin level, a marker of blood contamination in salivary analysis

Cited 3 time in Web of Science Cited 4 time in Scopus
Authors
Kang, Jeong-Hyun; Lee, Yeon-Hee; Kho, Hong-Seop
Issue Date
2018-03-21
Publisher
BioMed Central
Citation
BMC Oral Health, 18(1):49
Keywords
SalivaBloodTransferrinGingival inflammation
Abstract
Background
Diagnostic value of whole saliva may be compromised when blood contamination is present in saliva samples. Measuring transferrin level in saliva samples has been used for detecting the level of blood contamination in saliva. The aim of this study was to investigate the validity of transferrin as a proper biomarker for blood contamination in whole saliva.

Methods
Thirty younger (mean age: 25.9 ± 2.1 years) and twenty older (mean age: 65.1 ± 9.0 years) females were included. The index reflecting overall gingival inflammation (total gingival index), salivary flow rate, and salivary concentration and secretion rate of transferrin of each subject were analyzed.

Results
Salivary transferrin concentrations and secretion rates were higher in the younger females than in the older ones despite a lower total gingival index in the younger females. The total gingival index showed no significant correlations with the concentration or secretion rate of transferrin in either unstimulated or stimulated whole saliva of younger and older subjects. The salivary concentration of transferrin showed negative correlations with the flow rate of saliva in both the younger and older groups. There were significant positive correlations between the salivary concentrations and secretion rates of transferrin in both the younger and older groups.

Conclusions
Salivary transferrin levels could be affected by other factors as well as the level of blood contamination. The influences of age, gonadal hormones, salivary flow rate, and chewing performance need to be considered when using the salivary level of transferrin as a blood contamination marker.
ISSN
1472-6831
Language
English
URI
http://hdl.handle.net/10371/139756
DOI
https://doi.org/10.1186/s12903-018-0510-x
Files in This Item:
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dental Research Institute (치학연구소)Journal Papers (저널논문_치학연구소)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse