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Cardia cancer is different from non- cardia cancer in terms of local and systemic immune responses : 비분문부암과 다른 국소-전신 면역반응을 보이는 분문부암
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 이혁준 | - |
dc.contributor.author | 김형일 | - |
dc.date.accessioned | 2018-05-28T16:57:51Z | - |
dc.date.available | 2018-05-28T16:57:51Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.other | 000000151360 | - |
dc.identifier.uri | https://hdl.handle.net/10371/141006 | - |
dc.description | 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의학과, 2018. 2. 이혁준. | - |
dc.description.abstract | Introduction: This study sought to investigate the prognostic significance of tumor infiltrating lymphocytes (TILs) in respect to the prognostic nutritional index (PNI), neutrophil-to-lymphocyte ratio (NLR), and the topographic location of gastric tumors.
Methods: Retrospective data from a prospectively maintained database of gastric cancer patients who underwent gastrectomy from January 2001 to December 2010 at a single center were retrieved. The distribution and prognostic significance of a subset of TILs using immunohistochemical staining for CD3, CD4, CD8, Foxp3, and granzyme B in 416 gastric cancer patients were evaluated. The PNI was calculated using preoperative laboratory values of 7781 gastric cancer patients. TILs and PNI were analyzed according to topographic location. Results: Gastric cancers in the cardia, compared to other locations, were associated with significantly lower CD8 and higher Foxp3 and granzyme B counts, without significant differences in PNI or NLR values. In cardia- localized cancer, multivariate analysis for clinicopathological and immunological factors revealed that lymph node metastasis and a high Foxp3/CD4 ratio were independent poor prognostic factors for overall survival. In non-cardia cancer, total gastrectomy, advanced T-classification, lymph node metastasis, low Foxp3, and low PNI were all poor prognostic factors. Conclusions: The distribution and prognostic impact of TILs and PNIs varied according to the longitudinal location of the cancer. Regulatory T lymphocytes were an unfavorable prognostic factor in cardia cancer and a favorable prognostic factor in non-cardia cancer. | - |
dc.description.tableofcontents | General Introduction 1
Chapter I: Local immune responses in cardia cancer 4 Introduction 5 Methods 7 Results 12 Discussion 17 Chapter II: Systemic immune responses in gastric cancer 20 Introduction 21 Methods 23 Results 26 Discussion 36 Chapter III: Local and systemic immune responses in cardia and non-cardia cancer 39 Introduction 40 Methods 42 Results 47 Discussion 55 References 58 Abstract in Korean 71 | - |
dc.format | application/pdf | - |
dc.format.extent | 7888911 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Tumor infiltrating lymphocytes | - |
dc.subject | regulatory T-lymphocytes | - |
dc.subject | prognostic nutritional index | - |
dc.subject | cardia cancer | - |
dc.subject | gastric cancer | - |
dc.subject | prognosis | - |
dc.subject | immune responses | - |
dc.subject.ddc | 610 | - |
dc.title | Cardia cancer is different from non- cardia cancer in terms of local and systemic immune responses | - |
dc.title.alternative | 비분문부암과 다른 국소-전신 면역반응을 보이는 분문부암 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Hyoung-Il Kim | - |
dc.description.degree | Doctor | - |
dc.contributor.affiliation | 의과대학 의학과 | - |
dc.date.awarded | 2018-02 | - |
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