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Development and application of constant flow generating injector with pulse energy source as driving force : 펄스 에너지원을 구동력으로 하는 균일 유동 마이크로젯 인젝터 개발 및 응용 기술

DC Field Value Language
dc.contributor.advisor여재익-
dc.contributor.author함휘찬-
dc.date.accessioned2018-05-29T03:14:18Z-
dc.date.available2018-05-29T03:14:18Z-
dc.date.issued2018-02-
dc.identifier.other000000149417-
dc.identifier.urihttps://hdl.handle.net/10371/141379-
dc.description학위논문 (석사)-- 서울대학교 대학원 : 공과대학 기계항공공학부, 2018. 2. 여재익.-
dc.description.abstractA narrow nozzle ejects a microjet of 150 μm in diameter with a velocity of 140 m/s a by the laser-induced bubble expansion in the designed injector. The pulsed form of the driving force at a period of 10 Hz from the connected Er:YAG laser makes it possible for multiple microjet ejections aimed at delivery of drugs into a skin target. The pulsed actuation of the microjet generation is however susceptible to the air leak which can cause the outside air to enter into the momentarily de-pressurized nozzle, leading to a significant reduction of the microjet speed during the pulsed administering of the drug. In the present study, we designed a ball-check valve injector which is less prone to an unwanted air build up inside the nozzle by controlling the nozzle pressure to remain above ambient pressure at all times. The new device is rigorously compared against the reported performance of the previous injector and has shown to maintain about 97% of the initial microjet speed regardless of the number of shots administered-
dc.description.abstractlikewise, the drug penetration depth into a porcine skin is improved to 1.5 to 2.25 times the previously reported penetration depths.-
dc.description.tableofcontentsCHAPTER 1 INTRODUCTION 1
CHAPTER 2 Uniform microjet flow generation through check valve and its application technology 3
2.1 Materials and methods 3
2.1.1. Pressure chamber and drug nozzle separated by an elastic membrane 4
2.1.2. A ball-check valve nozzle 5
2.1.3. Measurements of jet speed and ball motion 6
2.1.4. Tissue targets 7
2.2 Results and discussion 8
2.2.1. Adverse air inflow into nozzle causing injector performance degradation 8
2.2.2. Penetration on porcine skins 10
2.2.3. External syringe-type drug reservoir 12
CHAPTER 3 Optimization of the microjet performance - Analysis 16
3.1 Assumptions and dominant variables 16
3.2 Modeling inside valve actuation 17
3.3 Simulation & experiment of inside valve actuation 19
CHAPTER 4 Conclusion 25
References 27
Abstract 29
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dc.formatapplication/pdf-
dc.format.extent1134862 bytes-
dc.format.mediumapplication/pdf-
dc.language.isoen-
dc.publisher서울대학교 대학원-
dc.subjectMicrojet-
dc.subjectLaser-induced bubble-
dc.subjectBall-chenck valve-
dc.subjectNeedle-free-
dc.subjectDrug-delivery-
dc.subjectJet injection-
dc.subject.ddc621-
dc.titleDevelopment and application of constant flow generating injector with pulse energy source as driving force-
dc.title.alternative펄스 에너지원을 구동력으로 하는 균일 유동 마이크로젯 인젝터 개발 및 응용 기술-
dc.typeThesis-
dc.contributor.AlternativeAuthorHam hwi-chan-
dc.description.degreeMaster-
dc.contributor.affiliation공과대학 기계항공공학부-
dc.date.awarded2018-02-
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