Publications
Detailed Information
Local and Controlled Delivery of Triamcinolone for the Prevention of Fibrosis around Silicone Implants : 실리콘 임플란트 주변의 섬유화 예방을 위한 트리암시놀론의 국소적 제어 전달
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 최영빈 | - |
dc.contributor.author | 전범수 | - |
dc.date.accessioned | 2018-05-29T03:38:25Z | - |
dc.date.available | 2018-05-29T03:38:25Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.other | 000000150491 | - |
dc.identifier.uri | https://hdl.handle.net/10371/141609 | - |
dc.description | 학위논문 (석사)-- 서울대학교 대학원 : 공과대학 협동과정 바이오엔지니어링전공, 2018. 2. 최영빈. | - |
dc.description.abstract | I propose silicone implants capable of the local, controlled release of a glucocorticoid drug, triamcinolone acetonide (TA), for the prevention of fibrosis. The shells of these silicone implants were coated with two different loading amounts of TA, which could release the drug in a sustained manner for 12 weeks. The drug-loaded implants were inserted into the subcutaneous space in living rats, and the tissues were biopsied at scheduled times during 12 weeks. For the drug-coated implants, the capsule thickness and collagen density decreased compared with those of the non-coated implant. Because of the effect of TA, inflammation and the expression of pro-inflammatory cytokines, such as TNF-α and IL-1β, were downregulated, thereby decreasing the number of monocytes during acute inflammation. This effect in turn decreased the number of macrophages at the later stage of inflammation, leading to the expression of less TGF-β and consequently fewer fibroblasts and myofibroblasts. Notably, with an appropriate dose of TA, skin and muscle atrophy, major side effects of TA, could be avoided while still effectively reducing fibrosis. Therefore, I conclude that the local, sustained release of an appropriate dose of a glucocorticoid drug can be a promising strategy for safely preventing fibrosis around silicone implants. | - |
dc.description.tableofcontents | 1. Introduction 1
1.1 Background knowledge 1 1.2 Strategy 2 2. Materials and Methods 4 2.1 Materials 4 2.2 Preparation of silicone implant samples 5 2.3 Characterization 7 2.4 In vitro drug release experiments 7 2.5 In vivo animal study 8 2.6 Staining 9 2.7 Stained image analysis 10 2.8 Statistical analysis 12 3. Results 13 3.1 Implant characterization 13 3.2 Anti-fibrotic effects 17 3.3 Inflammation 20 3.4 Fibrotic factors 26 3.5 Drug side effects 30 4. Discussion 33 5. Conclusion 36 6. References 37 국문초록 42 | - |
dc.format | application/pdf | - |
dc.format.extent | 2475998 bytes | - |
dc.format.medium | application/pdf | - |
dc.language.iso | en | - |
dc.publisher | 서울대학교 대학원 | - |
dc.subject | Controlled release | - |
dc.subject | Silicone implant | - |
dc.subject | Fibrosis | - |
dc.subject | Inflammation | - |
dc.subject | Glucocorticoid | - |
dc.subject | Triamcinolone | - |
dc.subject.ddc | 660.6 | - |
dc.title | Local and Controlled Delivery of Triamcinolone for the Prevention of Fibrosis around Silicone Implants | - |
dc.title.alternative | 실리콘 임플란트 주변의 섬유화 예방을 위한 트리암시놀론의 국소적 제어 전달 | - |
dc.type | Thesis | - |
dc.contributor.AlternativeAuthor | Jeon Beom Su | - |
dc.description.degree | Master | - |
dc.contributor.affiliation | 공과대학 협동과정 바이오엔지니어링전공 | - |
dc.date.awarded | 2018-02 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.