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Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yun, Ki Wook | - |
dc.contributor.author | Choi, Eun Hwa | - |
dc.contributor.author | Lee, Hoan Jong | - |
dc.contributor.author | Kang, Jin Han | - |
dc.contributor.author | Kim, Kyung-Hyo | - |
dc.contributor.author | Kim, Dong Soo | - |
dc.contributor.author | Kim, Yae-Jean | - |
dc.contributor.author | Eun, Byung Wook | - |
dc.contributor.author | Oh, Sung Hee | - |
dc.contributor.author | Cho, Hye-Kyung | - |
dc.contributor.author | Hong, Young Jin | - |
dc.contributor.author | Kim, Kwang Nam | - |
dc.contributor.author | Kim, Nam Hee | - |
dc.contributor.author | Kim, Yun-Kyung | - |
dc.contributor.author | Lee, Hyunju | - |
dc.contributor.author | Lee, Taekjin | - |
dc.contributor.author | Kim, Hwang Min | - |
dc.contributor.author | Cho, Eun Young | - |
dc.contributor.author | Kim, Chun Soo | - |
dc.contributor.author | Park, Su Eun | - |
dc.contributor.author | Oh, Chi Eun | - |
dc.contributor.author | Jo, Dae Sun | - |
dc.contributor.author | Choi, Young Youn | - |
dc.contributor.author | Lee, Jina | - |
dc.date.accessioned | 2018-07-27T05:33:19Z | - |
dc.date.available | 2018-07-27T14:34:32Z | - |
dc.date.issued | 2018-06-08 | - |
dc.identifier.citation | BMC Infectious Diseases, 18(1):268 | ko_KR |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/10371/142756 | - |
dc.description.abstract | Background
Understanding the population genetics of pneumococci will allow detection of changes in the prevalence of circulating genotypes and evidence for capsular switching. We aimed to analyze the genetic structure of invasive pneumococcal isolates obtained from children before and after the use of pneumococcal conjugate vaccines (PCVs) in Korea. Methods A total of 285 invasive pneumococcal isolates were analyzed using serotyping, multilocus sequence typing, and antimicrobial susceptibility testing. We classified the isolation year to pre-PCV7 (1995–2003; n = 70), post-PCV7 (2004–2010; n = 142), and post-PCV13 (2011–2013; n = 73) periods. Results Of the 10 clonal complexes (CCs), antibiotic-resistant international clones, CC320 (31.6%), CC81 (14.7%), and CC166 (6.7%) were the main complexes. Serotype 19A was the main serotype of CC320 throughout the periods. Serotypes of CC81 mainly comprised of 23F (53.3%) in pre-PCV7 period and replaced by non-vaccine types (NVTs; 6C [10%], 13 [30%], 15A [40%], and 15B/C [20%]) in post-PCV13 period. The main serotype responsible for CC166 also changed from 9V (80%) in pre-PCV7 to NVT 11A (50%) in post-PCV13 periods. Non-susceptibility to penicillin (42.3%) was the highest in CC320, increasing from 0 to 76%. Conclusion The genetic structures of invasive pneumococcal isolates in Korean children have changed concomitantly with serotype after the implementation of PCVs. | ko_KR |
dc.description.sponsorship | This research was supported by the Ministry of health and Welfare, Republic of Korea (HI-12C0756). The funding body did not intervene in any step of the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Invasive pneumococcal diseases | ko_KR |
dc.subject | Pneumococcal conjugate vaccine | ko_KR |
dc.subject | Multilocus sequence typing | ko_KR |
dc.subject | Children | ko_KR |
dc.title | Genetic structures of invasive Streptococcus pneumoniae isolates from Korean children obtained between 1995 and 2013 | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 윤기욱 | - |
dc.contributor.AlternativeAuthor | 최은화 | - |
dc.contributor.AlternativeAuthor | 이환종 | - |
dc.contributor.AlternativeAuthor | 강진한 | - |
dc.contributor.AlternativeAuthor | 김경효 | - |
dc.contributor.AlternativeAuthor | 김동수 | - |
dc.contributor.AlternativeAuthor | 김예진 | - |
dc.contributor.AlternativeAuthor | 은병욱 | - |
dc.contributor.AlternativeAuthor | 오성희 | - |
dc.contributor.AlternativeAuthor | 조혜경 | - |
dc.contributor.AlternativeAuthor | 홍영진 | - |
dc.contributor.AlternativeAuthor | 김광남 | - |
dc.contributor.AlternativeAuthor | 김남희 | - |
dc.contributor.AlternativeAuthor | 김윤경 | - |
dc.contributor.AlternativeAuthor | 이현주 | - |
dc.contributor.AlternativeAuthor | 이택진 | - |
dc.contributor.AlternativeAuthor | 김황민 | - |
dc.contributor.AlternativeAuthor | 조은영 | - |
dc.contributor.AlternativeAuthor | 김천수 | - |
dc.contributor.AlternativeAuthor | 박수은 | - |
dc.contributor.AlternativeAuthor | 오지은 | - |
dc.contributor.AlternativeAuthor | 조대선 | - |
dc.contributor.AlternativeAuthor | 최영윤 | - |
dc.contributor.AlternativeAuthor | 이지나 | - |
dc.identifier.doi | 10.1186/s12879-018-3177-7 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2018-06-10T03:44:45Z | - |
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