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Odontogenic ameloblast-associated protein (ODAM) in gingival crevicular fluid for site-specific diagnostic value of periodontitis: a pilot study

DC Field Value Language
dc.contributor.authorLee, Hye-Kyung-
dc.contributor.authorKim, Soo Jin-
dc.contributor.authorKim, Young Ho-
dc.contributor.authorKo, Youngkyung-
dc.contributor.authorJi, Suk-
dc.contributor.authorPark, Joo-Cheol-
dc.date.accessioned2018-11-14T05:52:10Z-
dc.date.available2018-11-14T14:53:11Z-
dc.date.issued2018-08-24-
dc.identifier.citationBMC Oral Health, 18(1):148ko_KR
dc.identifier.issn1472-6831-
dc.identifier.urihttp://hdl.handle.net/10371/143537-
dc.description.abstractBackground
Odontogenic Ameloblast-Associated Protein (ODAM) in gingival crevicular fluid (GCF) can provide evidence of the detachment of junctional epithelium from the tooth surface by periodontitis. This study sought to investigate the ability of ODAM to reflect the severity of periodontitis at a site-specific level; thus whether there was a relationship between clinical diagnostic parameters and the value of ODAM in GCF was analyzed.

Methods
Eight periodontitis patients with various severities were enrolled, and the clinical parameters and samples of GCF were obtained from 44 to 60 sites of each subject. The ODAM concentration was quantified by enzyme-linked immunosorbent assay. Correlation analyses between clinical parameters and ODAM values and unadjusted and adjusted (linear) mixed model analyses were performed. The accuracy of ODAM to reflect sites having a probing depth (PD) ≥ 5 mm and a positive bleeding on probing (BOP) was evaluated by receiver-operating characteristic analysis.

Results
A total of 424 GCF samples were collected. The mean ODAM concentration from each patient varied from 0.2 to 1.52 ng/ml. Correlations between PD or clinical attachment level (CAL) and ODAM values were found (p <  0.0001). An adjusted linear mixed model showed that PD or CAL were associated with ODAM values (p <  0.05). The area under the curve of ODAM, which reflected sites with PD ≥ 5 mm and positive BOP, was 0.661 (p <  0.0001).

Conclusion
This result shows the possibility of GCF ODAM as a site-specific biomarker for periodontal tissue destruction.
ko_KR
dc.description.sponsorshipThis research was supported by a grant from the Korean Health Technology R&D project, Ministry of Health & Welfare, Republic of Korea (HI16C0220). The funder had no role in the design of the study and collection, analysis, and interpretation of data or in the writing of the manuscript.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectOdontogenic ameloblast-associated proteinko_KR
dc.subjectODAMko_KR
dc.subjectPeriodontitisko_KR
dc.subjectGingival crevicular fluidko_KR
dc.subjectBiomarkerko_KR
dc.titleOdontogenic ameloblast-associated protein (ODAM) in gingival crevicular fluid for site-specific diagnostic value of periodontitis: a pilot studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이혜경-
dc.contributor.AlternativeAuthor김수진-
dc.contributor.AlternativeAuthor김영호-
dc.contributor.AlternativeAuthor고영경-
dc.contributor.AlternativeAuthor지석-
dc.contributor.AlternativeAuthor박주철-
dc.identifier.doi10.1186/s12903-018-0609-0-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2018-08-26T03:22:03Z-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dental Research Institute (치학연구소)Journal Papers (저널논문_치학연구소)
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