SHERP

Pan-cancer analysis of tumor metabolic landscape associated with genomic alterations

Cited 1 time in webofscience Cited 0 time in scopus
Authors
Choi, Hongyoon; Na, Kwon Joong
Issue Date
2018-10-17
Publisher
BioMed Central
Citation
Molecular Cancer, 17(1):150
Keywords
Tumor mutation burdenMetabolic landscapeCancer metabolismPan-cancer analysisDriver gene mutation
Abstract
Although metabolic alterations are one of the hallmarks of cancer, there is a lack of understanding of how metabolic landscape is reconstituted according to cancer progression and which genetic alterations underlie its heterogeneity within cancer cells. Here, the configuration of the metabolic landscape according to genetic alteration is examined across 7648 subjects representing 29 cancers. The metabolic landscape and its reconfiguration according to the accumulated mutation maintained characteristics of their tissue of origin. However, there were some common patterns across cancers in terms of the association with cancer progression. Carbohydrate and pyrimidine metabolism showed the highest positive correlation with tumor metabolic burden and they were also common poor prognostic pathways in several cancer types. We additionally examined whether genetic alterations associated with the heterogeneity of metabolic landscape. Genetic alterations associated with each metabolic pathway differed between cancers, however, they were a part of cancer drivers in most cancer types.
ISSN
1476-4598
Language
English
URI
http://hdl.handle.net/10371/145177
DOI
https://doi.org/10.1186/s12943-018-0895-9
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
College of Medicine/School of Medicine (의과대학/대학원)Thoracic Surgery (흉부외과학전공)Journal Papers (저널논문_흉부외과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse