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Metabolic syndrome, not menopause, is a risk factor for hypertension in peri-menopausal women

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Authors
Oh, Gyu Chul; Kang, Kee Soo; Park, Chan Soon; Sung, Ho Kyung; Ha, Kyoung Hwa; Kim, Hyeon Chang; Park, Sungha; Ihm, Sang Hyun; Lee, Hae-Young
Issue Date
2018-10-15
Publisher
BioMed Central
Citation
Clinical Hypertension, 24(1):14
Keywords
HypertensionMetabolic syndromeMenopauseObesity
Abstract
Background
It has been long debated whether menopause itself is a risk factor for hypertension in peri-menopausal women. We aimed to assess the association between menopause and hypertension, and whether metabolic syndrome (MetS) has an influence on its effect.

Methods
Data for 1502 women aged 42 to 53 from the Korean Genome and Epidemiology Study (KoGES) database were retrospectively analyzed. The KoGES database consists of 10,038 participants, of which 52.6% (5275) were female. Subjects were followed up for 4 years, and compared according to menopausal status. Additionally, 1216 non-hypertensive subjects were separately analyzed to assess whether a change in menopausal status was associated with development of hypertension.

Results
The prevalence of hypertension, diabetes, and MetS for menopausal and non-menopausal subjects at baseline was 24.4% vs. 16.7%, 5.8% vs. 2.9%, and 25.4% vs. 16.6%, respectively (p < 0.01 for all comparisons). Among non-hypertensive subjects at baseline, prevalence of hypertension at 4-year follow-up was 9.4%, 19.7%, and 13.1% for non-menopausal, those who became menopause during follow-up, and those who were menopause at baseline, respectively. Development of hypertension was positively correlated with MetS (HR 3.90, 95% CI 2.51–6.07) and increased BMI (HR 1.09, 95% CI 1.03–1.16), while association with menopause was not significant.

Conclusions
Menopause is closely associated with increased incidence of hypertension, but the increase may not be attributable to menopause itself but to increased prevalence of MetS.
ISSN
2056-5909
Language
English
URI
http://hdl.handle.net/10371/145178
DOI
https://doi.org/10.1186/s40885-018-0099-z
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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