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Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis

Cited 2 time in Web of Science Cited 2 time in Scopus
Authors
Yun, Donghwan; Jang, Myoung-jin; An, Jung Nam; Lee, Jung Pyo; Kim, Dong Ki; Chin, Ho Jun; Kim, Yon Su; Lee, Dong-Sup; Han, Seung Seok
Issue Date
2019-03-12
Publisher
BioMed Central
Citation
BMC Nephrology. 2019 Mar 12;20(1):88
Keywords
Acute tubulointerstitial nephritisCytokineEnd-stage renal diseaseMortalitySteroid
Abstract
Background
Acute tubulointerstitial nephritis (ATIN) is an important cause of acute kidney injury and often a potentially reversible disease. However, the role of steroids in ATIN remains controversial and the underlying mechanisms remain unresolved.

Methods
A total of 113 adult patients with biopsy-proven ATIN were recruited from three tertiary referral centers. Of 102 patients with idiopathic or drug-induced ATIN, outcomes such as renal recovery, end-stage renal disease, and all-cause mortality were compared between the steroid-treated and non-treated groups. Plasma and urine inflammatory cytokine levels at the time of biopsy were analyzed in patients (n = 33) using a bead-based multiplex assay and compared with those of healthy individuals (n = 40).

Results
Steroids were used in 92 (81.4%) of the total patients and in 82 (80.3%) patients with idiopathic or drug-induced ATIN. The rate of renal recovery and the risks of end-stage renal disease and mortality were not different between the steroid-treated and non-treated groups. Despite using a propensity score matching method (n = 20 in each group), none of the outcomes were different between the two groups. Several cytokines, such as monocyte chemotactic protein-1, interferon-α, and interleukin-6 and interleukin-8 levels, were markedly elevated in plasma and urine of patients compared with those in healthy individuals. However, cytokines related to Th2 response, such as IL-10, IL-33, were not different between the two groups.

Conclusions
Steroid use does not affect the overall outcome of ATIN. Based on the fact that targeting therapy should be investigated to improve outcomes, the present cytokine results will be helpful for developing a novel therapy for ATIN.
ISSN
1471-2369
Language
English
URI
http://hdl.handle.net/10371/147201
DOI
https://doi.org/10.1186/s12882-019-1277-2
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Journal Papers (저널논문_의과학과)
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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