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An animal model of calcium oxalate urolithiasis based on a cyclooxygenase 2 selective inhibitor

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Authors
Jeong, Byong Chang; Park, Min Young; Kwak, Cheol; Kim, Bong Sub; Kim, Jung-In; Kim, Hyeon Hoe
Issue Date
2005-11-29
Publisher
Springer-Verlag
Citation
Urol Res. 2005 Dec;33(6):453-9. Epub 2005 Nov 26.
Keywords
AnimalsCalcium Oxalate/*analysisCyclooxygenase 2 Inhibitors/*toxicityDisease Models, AnimalKidney Tubules/drug effects/injuries/pathologyLactobacillus/drug effects/pathogenicity/physiologyMaleOxalobacter formigenes/drug effects/pathogenicity/physiologyPyrazoles/toxicityRatsRats, Sprague-DawleySulfonamides/toxicityUrinary Calculi/*chemistry/*etiology/pathology
Abstract
Our aim was to develop a stone-forming animal model involving renal tubular injury using a cyclooxygenase 2 selective inhibitor. Male Sprague-Dawley rats fed chow containing 3% sodium oxalate with or without 100 mg/kg celecoxib were compared to animals fed normal chow. Rats were killed after 2 or 4 weeks and the kidneys were harvested for morphological examination. Collections of 24-h urine were made before kidney harvest. After 2 weeks only a few crystals were observed in rats that received oxalate and celecoxib, but after 4 weeks more crystals were observed at the renal papilla than in rats that received only oxalate. Few crystals were found in rats fed normal chow with or without celecoxib. The urinary activities of gamma-glutamyl transpeptidase (GGT) were increased by celecoxib administration whereas creatinine clearance rates were unchanged. In rats fed oxalate, urinary oxalate excretion increased, but calcium excretion decreased. This model using a cyclooxygenase 2 selective inhibitor is a useful stone forming animal model involving mild renal tubular injury together with mild hyperoxaluria.
ISSN
0300-5623 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16311770

http://hdl.handle.net/10371/14737
DOI
https://doi.org/10.1007/s00240-005-0507-1
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College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
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