Publications
Detailed Information
Galactosylated liposomes for targeted co-delivery of doxorubicin/vimentin siRNA to hepatocellular carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Hea Ry | - |
dc.contributor.author | Jo, Hyun-Young | - |
dc.contributor.author | Park, James S. | - |
dc.contributor.author | Kim, Dong-Eun | - |
dc.contributor.author | Cho, Je-Yoel | - |
dc.contributor.author | Kim, Pyung-Hwan | - |
dc.contributor.author | Kim, Keun-Sik | - |
dc.creator | 조제열 | - |
dc.date.accessioned | 2019-04-25T01:49:29Z | - |
dc.date.available | 2020-04-05T01:49:29Z | - |
dc.date.created | 2018-01-10 | - |
dc.date.created | 2018-01-10 | - |
dc.date.issued | 2016-08 | - |
dc.identifier.citation | Nanomaterials, Vol.6 No.8p. pp.141 | - |
dc.identifier.issn | 2079-4991 | - |
dc.identifier.uri | https://hdl.handle.net/10371/149664 | - |
dc.description.abstract | The combination of therapeutic nucleic acids and chemotherapeutic drugs has shown great promise for cancer therapy. In this study, asialoglycoprotein receptors (ASGPR) targeting-ligand-based liposomes were tested to determine whether they can co-deliver vimentin siRNA and doxorubicin to hepatocellular carcinoma (HCC) selectively. To achieve this goal, we developed an ASGPR receptor targeted co-delivery system called gal-doxorubicin/vimentin siRNA liposome (Gal-DOX/siRNA-L). The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA. Previous studies have shown that Gal-DOX/siRNA-L inhibited tumor growth by combined effect of DOX and vimentin siRNA than single delivery of either DOX or vimentin siRNA. These Gal-DOX/siRNA-Ls showed stronger affinity to human hepatocellular carcinoma cells (Huh7) than other cells (lung epithelial carcinoma, A549). These liposomes also have demonstrated that novel hepatic drug/gene delivery systems composed of cationic lipid (DMKE: O,O'-dimyristyl-N-lysyl glutamate), cholesterol, galactosylated ceramide, POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine), and PEG(2000)-DSPE (distearoyl phosphatidyl ethanolamine) at 2:1:1:1:0.2 (moral ratios) can be used as an effective drug/gene carrier specifically targeting the liver in vivo. These results suggest that Gal-DOX-siRNA-L could effectively target tumor cells, enhance transfection efficacy and subsequently achieve the co-delivery of DOX and siRNA, demonstrating great potential for synergistic anti-tumor therapy. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | MDPI AG | - |
dc.title | Galactosylated liposomes for targeted co-delivery of doxorubicin/vimentin siRNA to hepatocellular carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/nano6080141 | - |
dc.citation.journaltitle | Nanomaterials | - |
dc.identifier.wosid | 000380769600005 | - |
dc.identifier.scopusid | 2-s2.0-84983319442 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201634055 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A078834 | - |
dc.description.srnd | CITE_RATE:3.553 | - |
dc.description.srnd | FILENAME:Galactosylated Liposomes for Targeted.pdf | - |
dc.description.srnd | DEPT_NM:수의학과 | - |
dc.description.srnd | EMAIL:jeycho@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/00115a52-4dd5-4759-bea3-c76329a04973/link | - |
dc.citation.endpage | 141 | - |
dc.citation.number | 8 | - |
dc.citation.volume | 6 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Cho, Je-Yoel | - |
dc.identifier.srnd | T201634055 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MULTIDRUG-RESISTANT CANCER | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | COMBINATIONS | - |
dc.subject.keywordPlus | HEPATOCYTES | - |
dc.subject.keywordPlus | VIMENTIN | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordAuthor | targeted liposomes | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | vimentin siRNA | - |
dc.subject.keywordAuthor | combination therapy | - |
dc.subject.keywordAuthor | co-delivery | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.