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College of Medicine/School of Medicine (의과대학/대학원)
Surgery (외과학전공)
Journal Papers (저널논문_외과학전공)
Genetic polymorphisms of eNOS, hormone receptor status, and survival of breast cancer
- Issue Date
- 2006-07-06
- Publisher
- Springer Verlag
- Citation
- Breast Cancer Res Treat. 2006 Nov;100(2):213-8. Epub 2006 Jul 4
- Keywords
- Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/chemistry/*genetics/mortality ; Female ; Humans ; Middle Aged ; Nitric Oxide Synthase Type III/*genetics ; Receptors, Estrogen/*analysis ; Receptors, Progesterone/*analysis ; Polymorphism, Genetic
- Abstract
- The endothelial cell-specific form of nitric oxide synthase (eNOS) may play an important role in tumor progression via angiogenesis or apoptosis. We studied eNOS -786T > C and 894G > T (Glu298Asp), two functionally significant SNPs, in relation to hazard of breast cancer recurrence or death in 873 women with incident, non-metastatic breast cancer, recruited from two teaching hospitals in Seoul, Korea, 1995-2002. Hazards were estimated by Cox proportional hazard models, in relation to genotype, adjusting for hormone receptor status, lymph node involvement, and tumor size. Women carriers of the eNOS -786C allele had significantly increased hazards of breast cancer recurrence or death, compared with women having the TT genotype (HR = 2.1, 95% CI = 1.03-4.33); risks increased up to 3-fold in ER positive cases (HR = 3.2, 95% CI = 0.95-10.50). The hazard was also increased in eNOS 894T carriers, however, it did not reach statistical significance (HR = 1.8, 95% CI = 0.85-3.93). The combined genotypes containing -786C or 894T was associated with a 2.5-fold risk, compared to the TT-GG genotypes, the most dominant genotype combination (95% CI = 1.29-4.68), with the greatest risks in ER positive cases (HR = 4.9, 95% CI = 1.31-18.36). These results indicate that the eNOS -786C polymorphism, and possibly the 894T polymorphism, are associated with breast cancer recurrence and death, particularly in women with ER positive tumors.
- ISSN
- 0167-6806 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16821086
https://hdl.handle.net/10371/15273
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